Fucoxanthin exert dose-dependent antifibrotic and anti-inflammatory effects on CCl-induced liver fibrosis.

The lack of an effective non-surgical liver fibrosis treatment is a major problem in hepatology. Fucoxanthin is a marine xanthophyll that exhibits anti-inflammatory, antioxidant, and hepatoprotective properties, thereby indicating its potential effectiveness in the treatment of liver fibrosis. The study aims to investigate the antifibrotic and anti-inflammatory effects of fucoxanthin and its main mechanisms on carbon tetrachloride (CCl)-induced liver fibrosis in 50 outbred ICR/CD1 mice.

Trapping of two-component light bullets in a gradient waveguide with normal group dispersion.

In this paper we consider the process of the second harmonic generation in a gradient waveguide, taking into account diffraction and relatively weak temporal dispersion. Using the slowly varying envelope approximation and neglecting the dispersion of the nonlinear part of the response of the medium we obtain the system of parabolic equations for the envelopes of both harmonics. We also derive integrals of motion of this system.

Planar light bullets under conditions of second-harmonic generation.

We study solutions to second-harmonic-generation equations in two-dimensional media with anomalous dispersion. The analytical solution is obtained in an approximate form of the planar spatiotemporal two-component soliton by means of the averaged Lagrangian method. It is shown that a decrease in the amplitudes of both soliton components and an increase in the value of the transverse coordinate are accompanied by an increase in their temporal duration.

Hole-vortex solitons.

Three-dimensional two-component solitons, propagating in long-short wave resonance mode, are predicted. If the spectrum of the short-wave component lies in the area of normal group velocity dispersion, these solitons have transverse structure in the form of hole-vortex field defects on an infinite background. In the opposite case two-component "bullets" or the "bright" vortex and the "bullet" with a hole in the center can exist.