A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria and .

It has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on H01 and 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and cultivation system, and it may have both enhancing and counteracting effects. The antagonistic effect of the hormone was observed mostly on hydrophobic surfaces, whereas the additive effect was observed on hydrophilic surfaces like glass.

Structure of cell-wall glycopolymers of Micrococcus luteus C01.

Glycopolymers of two types were isolated from the cell wall of Micrococcus luteus C01 by stepwise extraction with cold and hot 10% aq CClCOH. The following structures of the glycopolymers were established by compositional analysis and 1D and 2D NMR spectroscopy: where L-Glu indicates glutamic acid.

The Impact of Norepinephrine on Mono-Species and Dual-Species Staphylococcal Biofilms.

The effect of norepinephrine ("NE") on Gram-negative bacteria is well characterized; however, little is known about the impact of NE on cutaneous Gram-positive skin residents, especially staphylococci. In this study, the impact of NE on monospecies and dual-species biofilms of and model strains was investigated for the first time. Biofilms were grown in two different models (on polytetrafluoroethylene ("PTFE") cubes and glass microfiber filters ("GMFFs")) and additionally kinetic measurements of bacterial growth was performed.

Multiple Drug-Induced Stress Responses Inhibit Formation of Escherichia coli Biofilms.

In most ecosystems, bacteria exist primarily as structured surface-associated biofilms that can be highly tolerant to antibiotics and thus represent an important health issue. Here, we explored drug repurposing as a strategy to identify new antibiofilm compounds, screening over 1,000 compounds from the Prestwick Chemical Library of approved drugs for specific activities that prevent biofilm formation by Most growth-inhibiting compounds, which include known antibacterial but also antiviral and other drugs, also reduced biofilm formation. However, we also identified several drugs that were biofilm inhibitory at doses where only a weak effect or no effect on planktonic growth could be observed.

Draft Genome Sequence of Kytococcus schroeteri Strain H01, Isolated from Human Skin.

strain H01 was isolated from the skin of a healthy volunteer who underwent erythromycin treatment for a skin disorder 1 year prior. The draft genome consists of 2.38 Mb, a G+C content of 73.