Late Myelosuppressive Action of Programmed Chemotherapy in Acute Lymphoblastic Leukemia in Children.

The capability of peripheral blood leukocytes and bone marrow cells to spontaneous apoptosis was studied in 36 children with ALL remission at various periods after polychemotherapy withdrawal. The enhancement of apoptotic activity has been revealed to be the universal mechanism of delayed effect of antileukemic chemotherapy for all the compartments of hemopoiesis, including granulocyte/macrophage precursors. The expression of this phenomenon is decreasing with the time period elapsed after treatment withdrawal.