Model for Predicting the Effect of Sibutramine Therapy in Obesity.

The development of models predicting response to weight loss therapy using sibutramine is found in only a few cases. The objective of the work is to develop a data-driven method of personalized recommendation for obesity treatment that would predict the response to sibutramine based on the current set of patient parameters. The decision system is built on the XGBoost classification algorithm along with recursive feature selection and Shapley data valuation.

Role of Brown Adipose Tissue in Metabolic Health and Efficacy of Drug Treatment for Obesity.

(1) : Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, and its activation has become a new object as both a determinant of metabolic health and a target for therapy. This study aimed to identify the relationships between the presence of BAT, parameters that characterize metabolic health (glucose, lipids, blood pressure (BP)), and the dynamics of body mass index (BMI) during weight-reducing therapy. (2) : The study included 72 patients with obesity.

Atlantic Water warming increases melt below Northeast Greenland's last floating ice tongue.

The 79 North Glacier (79NG) features Greenland's largest floating ice tongue. Even though its extent has not changed significantly in recent years, observations have indicated a major thinning of the ice tongue from below. Both ocean warming and an increase in subglacial discharge from the ice sheet induced by atmospheric warming could increase the basal melt; however, available observations alone cannot tell which of these is the main driver.

A Prospective Comparison of Transrectal Standard, Cognitive, Transperineal Fusion, and Mapping Prostate Biopsy for Cancer Detection.

The aim of this research was to compare the clinically significant prostate cancer (csPCa) detection rate (International Society of Urological Pathology [ISUP] ≥2) for the four biopsy methods: transrectal ultrasound-guided biopsy (TRUS-GB), cognitive transrectal biopsy (COG-TB), fusion transperineal biopsy (FUS-TB), and transperineal template mapping biopsy (TPMB). The inclusion criteria were as follows: prostate-specific antigen (PSA) >2 ng/mL, and/or positive digital rectal examination (DRE), and/or suspicious lesion on transrectal ultrasound (TRUS) and Prostate Imaging Reporting and Data System (Pi-RADS) v2.1 ≥ 3 score.

Regulation of the Concentration Heterogeneity and Thermal Expansion Coefficient in the Metastable Invar FeNi Alloy.

Mössbauer spectroscopy and electron microscopy study of the active redistribution of Ni atoms during the process of polymorphous transformation α→γ in the metastable FeNi alloy revealed that slow heating (at the rate of 0.2 K/min) results in the depletion of the initial α-phase with a beneficiation of developing disperse γ-phase plates according to the equilibrium diagram. A regulation possibility of the concentration heterogeneity and austenite thermal expansion coefficient resulted from the polymorphous transformation α→γ was shown.

Delayed Antarctic sea-ice decline in high-resolution climate change simulations.

Despite global warming and Arctic sea-ice loss, on average the Antarctic sea-ice extent has not declined since 1979 when satellite data became available. In contrast, climate model simulations tend to exhibit strong negative sea-ice trends for the same period. This Antarctic sea-ice paradox leads to low confidence in 21st-century sea-ice projections.

Tensile Deformation and Fracture Behavior of API-5L X70 Line Pipe Steel.

Thermo-mechanical controlled processing (TMCP) is employed to obtain the required level of mechanical properties of contemporary HSLA steel plates utilized for gas and oil pipeline production. The strength and crack resistance of pipeline steels are mainly determined by its microstructure and crystallographic texture. In this study, the influence of the structural and textural states of industrially produced API-5L X70-X80 pipeline steels on tensile mechanical properties was analyzed.

Photoelectromagnetic Effect Induced by Terahertz Laser Radiation in Topological Crystalline Insulators PbSnTe.

Topological crystalline insulators form a class of semiconductors for which surface electron states with the Dirac dispersion relation are formed on surfaces with a certain crystallographic orientation. PbSnTe alloys belong to the topological crystalline phase when the SnTe content exceeds 0.35, while they are in the trivial phase at < 0.

Helicity-Sensitive Plasmonic Terahertz Interferometer.

Plasmonic interferometry is a rapidly growing area of research with a huge potential for applications in the terahertz frequency range. In this Letter, we explore a plasmonic interferometer based on graphene field effect transistor connected to specially designed antennas. As a key result, we observe helicity- and phase-sensitive conversion of circularly polarized radiation into dc photovoltage caused by the plasmon-interference mechanism: two plasma waves, excited at the source and drain part of the transistor, interfere inside the channel.

Non-equilibrium electron transport induced by terahertz radiation in the topological and trivial phases of Hg Cd Te.

Terahertz photoconductivity in heterostructures based on n-type Hg Cd Te epitaxial films both in the topological phase ( < 0.16, inverted band structure, zero band gap) and the trivial state ( > 0.16, normal band structure) has been studied.

Electron energy relaxation under terahertz excitation in (Cd Zn )As Dirac semimetals.

We demonstrate that measurements of the photo-electromagnetic effect using terahertz laser radiation provide an argument for the existence of highly conductive surface electron states with a spin texture in Dirac semimetals (Cd Zn )As. We performed a study on a range of (Cd Zn )As mixed crystals undergoing a transition from the Dirac semimetal phase with an inverse electron energy spectrum to trivial a semiconductor with a direct spectrum in the crystal bulk by varying the composition . We show that for the Dirac semimetal phase, the photo-electromagnetic effect amplitude is defined by the number of incident radiation quanta, whereas for the trivial semiconductor phase, it depends on the laser pulse power, irrespective of wavelength.

Terahertz polarization conversion with quartz waveplate sets.

We present the results of calculation and experimental testing of an achromatic polarization converter and a composite terahertz waveplate (WP), which are represented by sets of plane-parallel birefringent plates with in-plane birefringence axis. The calculations took into account the effect of interference, which was especially prominent when plates were separated by an air gap. The possibility of development of a spectrum analyzer design based on a set of WPs is also discussed.

Rhines scale and spectra of the beta-plane turbulence with bottom drag.

We study two-dimensional incompressible turbulence on the beta plane and propose a modification to the Rhines scale that takes into account the bottom friction. The modified Rhines scale is studied numerically, and found to predict accurately the jet number and the energy peak of the beta-plane turbulence for strong beta. The intermediate cases show a transition from the (isotropic) friction scale to the Rhines one, as the proper halting scale for the inverse cascade.