Publications by authors named "Sergey Baranov"
Front Mol Biosci
September 2024
Article Synopsis
- Dual inhibitors like lapatinib are effective for treating HER2-positive breast cancer, but their efficacy can be diminished by human serum and EGF.
- A study on the SK-BR-3 breast cancer cell line showed that lapatinib treatment changed the expression of 350 proteins, and combining it with serum or EGF reversed much of this change, negating growth inhibition.
- The research found that lapatinib increased proteins related to mitochondrial function and cellular respiration, marking enhanced respiration as a new mechanism of action for lapatinib in targeting HER2-positive cancer cells.
