Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention.

Background: New markers are needed to improve the effectiveness of serological screening for atrophic gastritis.

Aim: To develop a cost-effective method for serological screening of atrophic gastritis with a high level of sensitivity.

Methods: Of the 169 patients with atrophic gastritis, selected by the visual endoscopic Kimura-Takemoto method, 165 showed histological mucosal atrophy using the updated Kimura-Takemoto method.

Updated Kimura-Takemoto classification of atrophic gastritis.

Background: The Updated Sydney system for visual evaluation of gastric mucosal atrophy endoscopic observation is subject to sampling error and interobserver variability. The Kimura-Takemoto classification system was developed to overcome these limitations.

Aim: To compare the morphological classification of atrophic gastritis between the Kimura-Takemoto system and the Updated Sydney system.

Screening, Monitoring, and Treatment of Precancerous Atrophic Gastritis in the Prospective Study for Seven Years.

Aim: Develop a program to identify, treat, and prevent severe atrophic gastritis to reduce gastric cancer incidence and mortality.

Materials And Methods: In total, 2,847 people aged > 40 years old underwent serological noninvasive screening for atrophic gastritis by identifying postprandial gastrin-17 and pepsinogen-1 in the fasting state. Anti-H pylori IgG was found in 2,134 patients.