Publications by authors named "Sergej Susdalzew"
Article Synopsis
- Loss-of-function mutations in angiogenin, a ribonuclease, are linked to amyotrophic lateral sclerosis (ALS), highlighting its role in a stress response that has been conserved across species.
- Researchers identified specific tRNA fragments, particularly 5'ValCAC, produced by angiogenin, which are present in elevated amounts during ALS symptom onset and correlate with disease progression.
- The study indicates that higher levels of 5'ValCAC in serum may serve as a prognostic biomarker for ALS, suggesting an enhanced stress response in motor neurons that could lead to better survival outcomes.
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
Fabian M Nensa Martin H D Neumann Andreas Schrötter Andre Przyborski Thomas Mastalski Sergej Susdalzew
Mol Cell Proteomics
February 2014
FE65 is a cytosolic adapter protein and an important binding partner of amyloid precursor protein. Dependent on Thr668 phosphorylation in amyloid precursor protein, which influences amyloidogenic amyloid precursor protein processing, FE65 undergoes nuclear translocation, thereby transmitting a signal from the cell membrane to the nucleus. As this translocation may be relevant in Alzheimer disease, and as FE65 consists of three protein-protein interaction domains able to bind and affect a variety of other proteins and downstream signaling pathways, the identification of the FE65 interactome is of central interest in Alzheimer disease research.
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