Deep-learning based classification of a tumor marker for prognosis on Hodgkin's disease.

Purpose: Hodgkin's disease is a common malignant disorder in adolescent patients. Although most patients are cured, approximately 10%-15% of patients experience a relapse or have resistant disease. Furthermore, there are no definitive molecular predictors for early identification of patients at high risk of treatment failure to first line therapy.

Phenotypic diversity, population structure and stress protein-based capacitoring in populations of Xeropicta derbentina, a heat-tolerant land snail species.

The shell colour of many pulmonate land snail species is highly diverse. Besides a genetic basis, environmentally triggered epigenetic mechanisms including stress proteins as evolutionary capacitors are thought to influence such phenotypic diversity. In this study, we investigated the relationship of stress protein (Hsp70) levels with temperature stress tolerance, population structure and phenotypic diversity within and among different populations of a xerophilic Mediterranean snail species (Xeropicta derbentina).

Changes in selection regime cause loss of phenotypic plasticity in planktonic freshwater copepods.

Rapid phenotypic adaptation is critical for populations facing environmental changes and can be facilitated by phenotypic plasticity in the selected traits. Whereas recurrent environmental fluctuations can favour the maintenance or de novo evolution of plasticity, strong selection is hypothesized to decrease plasticity or even fix the trait (genetic assimilation). Despite advances in the theoretical understanding of the impact of plasticity on diversification processes, comparatively little empirical data of populations undergoing diversification mediated by plasticity are available.

Intraspecific variation in cellular and biochemical heat response strategies of Mediterranean Xeropicta derbentina [Pulmonata, Hygromiidae].

Dry and hot environments challenge the survival of terrestrial snails. To minimize overheating and desiccation, physiological and biochemical adaptations are of high importance for these animals. In the present study, seven populations of the Mediterranean land snail species Xeropicta derbentina were sampled from their natural habitat in order to investigate the intraspecific variation of cellular and biochemical mechanisms, which are assigned to contribute to heat resistance.