Publications by authors named "Sergei V Kostrov"
The failure of therapies directed at targets within cancer cells highlight the necessity for a paradigm change in cancer therapy. The attention of researchers has shifted towards the disruption of cancer cell interactions with the tumor microenvironment. A typical example of such a disruption is the immune checkpoint cancer therapy that disrupts interactions between the immune and the cancer cells.
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- BIEP is an extracellular serine protease from Bacillus intermedius that specifically cleaves peptide bonds next to glutamic acid.
- Its unique three-dimensional structure, analyzed in two crystal forms, features a beta-sandwich domain that differs from typical chymotrypsin structures.
- The binding of a 2-methyl-2,4-pentanediol molecule in the substrate site mimics glutamic acid and reveals key residues for substrate recognition, while also disrupting interactions between crucial catalytic residues.