Serum fibronectin levels in malignant and benign endometrial diseases.

Introduction: Endometrial cancer is currently the most common malignancy of the female reproductive system. The significance of the disease is determined by the search for additional biomarkers with the aim to optimize earlier diagnosis and to help for timely treatment. The objective of this study was to assess the serum levels of fibronectin (FN) in patients with malignant endometrial pathology and to compare them with patients with benign pathology and healthy women.

HLA-G Expression/Secretion and T-Cell Cytotoxicity in Missed Abortion in Comparison to Normal Pregnancy.

The main role of HLA-G is to protect the semi-allogeneic embryo from immune rejection by proper interaction with its cognate receptors on the maternal immune cells. Spontaneous abortion is the most common adverse pregnancy outcome, with an incidence rate between 10% and 15%, with immunologic dysregulation being thought to play a role in some of the cases. In this study, we aimed to detect the membrane and soluble HLA-G molecule at the maternal-fetal interface (MFI) and in the serum of women experiencing missed abortion (asymptomatic early pregnancy loss) in comparison to the women experiencing normal early pregnancy.

An outbreak of RSV infections in a neonatology clinic during the RSV-season.

Background: Respiratory syncytial virus (RSV) is the predominant cause of lower respiratory tract infections (LRTI) in infancy. Preterm infants with bronchopulmonary dysplasia (BPD) are at the highest risk of severe RSV-LRTI. This is a retrospective study that analyses a nosocomial outbreak of RSV infections in the Neonatology clinic of the University Hospital of Obstetrics and Gynecology, Sofia, 2019.

The incidence of small for gestational age neonates in singleton IVF pregnancies.

Introduction: Various factors related to an "" fertilization (IVF) procedure may influence the rate of small for gestational age (SGA) newborns in such pregnancies.

Aim: The aim of the study was to determine neonatal SGA incidence in singleton IVF pregnancies compared to spontaneous ones.

Materials And Methods: We conducted both a prospective and a retrospective study within the period of January 2013-December 2017, which included 336 patients with a singleton IVF pregnancy at the time of delivery - the study group (SG), and 493 women with a spontaneous conception - the control group (CG).