Pharmacokinetics and fate of free and encapsulated IRD800CW-labelled human BChE intravenously administered in mice.

Human butyrylcholinesterase (BChE) is an efficient bioscavenger of toxicants. Highly purified BChE was labelled with the near infrared fluorescent IRDye800CW. The goal was to determine the pharmacokinetics and fate of enzyme in mice.