Publications by authors named "Sergei Chekin"
After the Chernobyl accident in 1986, the "liquidators" or clean-up workers were among those who received the highest radiation doses to the thyroid from external radiation. Some were also exposed to radioiodines through inhalation or ingestion. A collaborative case-control study nested within cohorts of Belarusian, Russian and Baltic liquidators was conducted to evaluate the radiation-induced risk of thyroid cancer.
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- A case-control study was conducted among Chernobyl liquidators to examine how low- to medium-dose radiation exposure affected the risk of developing hematological malignancies.
- Researchers analyzed data from 117 cases of cancer, including types like leukemia and non-Hodgkin lymphoma, and compared them to 481 matched controls.
- The study concluded that there was a significantly elevated relative risk of cancers at radiation doses of 200 mGy and above, with some estimates being consistent with previous studies of atomic bomb survivors, though there are concerns about potential biases affecting the results.
The study investigated an association between the germline polymorphism at TP53 codon 72 and the development of papillary thyroid cancer (PTC) following exposure to radiation from the Chernobyl accident. TP53 genotype was examined in 48 pediatric/adolescent (age at diagnosis <18 years) and 68 adult post-Chernobyl patient with PTC, 53 adult patients with sporadic PTC and 313 healthy individuals from Russian-Ukrainian population. In addition, we evaluated loss of heterozygosity for TP53 and the allele expression ratio.
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