Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of Engl.

One new tirucallane triterpene named as canarimoic acid (), and three known analogues: 3-hydroxytirucalla-8,24-dien-21-oic acid (), 3-acetyltirucalla-8,24-diene-21oic acid () and 3-oxotirucalla-8,24-dien-21-oic () were isolated from the hydro-ethanolic crude extract of . Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound was the most active (MIC =16 µg/mL) against Typhi and Typhimurium followed by compound (MIC= 32 µg/mL) against Typhi and .

Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae).

Background: The use of herbal medicines as complements or alternatives to orthodox medicines has been on the increase. There has been the erroneous belief that these medicines are free from adverse effects. Schefflera barteri is popularly used in the West region of Cameroon for the treatment of various diseases such as diarrhea, spasm, pneumonia and animals bite.