Publications by authors named "Seret-Begue D"
Article Synopsis
- The study aimed to determine if diabetes is a risk factor for severe COVID-19 outcomes, independent of age and other health conditions, as diabetes is often seen in older individuals.
- Conducted as part of the CORONADO initiative, the research matched 2210 COVID-19 patients with and without diabetes by age, sex, and admission date, assessing outcomes like death and the need for invasive mechanical ventilation.
- Results showed that diabetes patients had higher rates of adverse outcomes within both 7 and 28 days of hospital admission, indicating that diabetes is a significant risk factor for severe COVID-19 complications regardless of age and comorbidity.
Article Synopsis
- This study examined how having metabolic and bariatric surgery (MBS) affects the outcomes of patients with type 2 diabetes (T2D) and severe obesity who are hospitalized for COVID-19.
- Researchers matched patients with a history of MBS to those without, focusing on their age, sex, and BMI at the time of either surgery or COVID-19 admission.
- Results showed that patients with MBS had significantly lower rates of invasive mechanical ventilation or death within 7 and 28 days following admission compared to those without MBS, suggesting better COVID-19 prognosis for MBS patients.
Article Synopsis
- The study examined sex differences in severe outcomes of COVID-19 among adults with diabetes, analyzing data from 2,380 hospitalized patients.
- Findings revealed that females had a lower risk of invasive mechanical ventilation, death, and ICU admission compared to males, although this female advantage was less evident in overall in-hospital mortality.
- The research highlighted specific predictors of death linked to sex, emphasizing the need for tailored COVID-19 management strategies based on biological differences.
Article Synopsis
- The CORONADO study examines outcomes in diabetic patients hospitalized due to COVID-19, focusing on hospital discharge and death rates within 28 days of admission.
- The study analyzed data from 2,796 patients, revealing that 50.2% were discharged and 20.6% died; factors influencing discharge included younger age and metformin use, while complications and severity indicators were linked to a higher risk of death.
- The findings aim to identify key prognostic factors to guide clinical decision-making for diabetic patients during the pandemic.
Article Synopsis
- The study aimed to investigate the effects of prior metformin use on the health outcomes of type 2 diabetes patients hospitalized for COVID-19.
- An analysis of 2,449 patients showed that metformin users generally had better survival rates and lower mortality compared to non-users, particularly noted at days 7 and 28 after admission.
- The conclusion suggests that metformin may reduce the risk of death in diabetes patients with COVID-19, indicating its potential beneficial effects during hospitalization.
Article Synopsis
- * Analysis was conducted on 1,965 patients from the CORONADO study, categorizing them into normal weight, overweight, and various obesity classes, revealing significant risks associated with higher BMI for intubation and death by day 7.
- * The findings suggest that while overweight and obesity worsen early COVID-19 prognosis in T2D patients, this negative effect is not observed in patients aged 75 and older, indicating a need for tailored management strategies for older adults.
Aim: The study evaluated the in-hospital prevalence of diabetes and hospital-related hyperglycaemia in a variety of French general wards.
Methods: The multicentre cross-sectional study involving nine French hospitals measured venous fasting plasma glucose (FPG) on a single day in patients hospitalized in adult medical and surgical short-term wards. Diabetes status and length of stay were recorded.
Background: Riedel's thyroiditis (RT) is a rare disease characterized by a chronic inflammatory lesion of the thyroid gland with invasion by a dense fibrosis. Publications of the imaging features of RT are scarce. To our knowledge, ultrasound elastography (USE) findings have not been previously reported.
View Article and Find Full Text PDFIntroduction: Electrophysiological exploration of neuropathies is a standard method of investigating the dysfunction of myelinated larger fibers (Aalpha, Abeta). However, this method cannot test dysfunctions in other fibers. To evaluate the smaller (Adelta) and unmyelinated fiber (C-fibers) lesions a quantitative method has been perfected: the study of the sensory thresholds (quantitative sensory testing: QST).
View Article and Find Full Text PDFObjective: Given the central role of the GnRH receptor (GnRHR) in the regulation of the gonadotrophin secretion, it might be implicated directly or indirectly in the pathogenesis of gonadotroph tumours.
Design: We determined if GnRHR mRNA was expressed in gonadotroph tumours using RT-PCR and analysed the GnRHR gene for the presence of mutations in its coding region, using direct sequencing of PCR products. Results were analysed according to the pattern of expression of alpha, beta-FSH and beta-LH subunit (SU) genes.
Objective: Free glycoprotein hormone alpha-subunit plasma levels have been reported to be increased in glycoprotein hormone-secreting adenomas and in acromegaly, but rarely in prolactinomas and in only two cases of Cushing's disease. The prevalence of elevated plasma alpha-subunit levels in patients with non-functioning adenomas is still unclear. In addition, no previous work has described plasma alpha-subunit levels in a comprehensive series of adenomas characterized by in-vivo secretion and/or immunocytochemistry.
View Article and Find Full Text PDFObjective: Gonadotroph adenomas are generally revealed by symptoms of mass effect at the stage of macroadenoma. Most of them hypersecrete FSH and/or gonadotrophin subunits. Rarely they hypersecrete LH, which could induce endocrinological symptoms.
View Article and Find Full Text PDFFifteen polyclonal antibodies (pAbs) and 14 monoclonal antibodies (mAbs) directed against hGH, hPRL, beta hFSH, beta hLH, beta hTSH and alpha-subunit were assessed by five different laboratories on normal and adenomatous pituitary tissues. This study aims at providing pathologists with a selected panel of antisera suitable for diagnosis, and appreciating the interest of the recently introduced mAbs. All the anti-hGH Abs proved to be specific (3 pAbs and 4 mAbs); three mAb out of four gave a few false-negative reactions.
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