Publications by authors named "Serene Roque"
Internal modifications in the CENP-A nucleosome modulate centromeric dynamics.
Epigenetics Chromatin
January 2018
Article Synopsis
- The study investigates posttranslational modifications of the centromere-specific histone CENP-A, focusing on lysine 124, which is acetylated during the cell cycle.
- Computational and in vivo analyses show that acetylation at K124 affects the histone structure, impacting CENP-C binding and increasing mitotic errors, while also changing the timing of centromeric replication.
- The findings highlight the role of dynamic modifications in CENP-A and their influence on vital processes like kinetochore assembly and mitosis.