Publications by authors named "Serena Piticchio"

Article Synopsis
  • - The growth and development of bones are controlled by bone morphogenetic proteins (BMPs), which are linked to various skeletal disorders, but BMP5 has not previously been connected to human skeletal malformations.
  • - A patient with two loss-of-function variants of BMP5 was identified, presenting a syndromic phenotype that includes skeletal dysostosis, physical abnormalities, and heart issues.
  • - The study suggests a novel association between BMP5 variants and various developmental anomalies affecting the ears, heart, and skeleton, enhancing our understanding of BMP5's role in human development.
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The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and in this setting short chain fatty acids (SCFA) are relevant. It was demonstrated that topical application of SCFA controls the inflammatory response in the psoriasis-like imiquimod (IMQ)-induced murine skin inflammation model.

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Fragment-based drug discovery (FBDD) emerged as a disruptive technology and became established during the last two decades. Its rationality and low entry costs make it appealing, and the numerous examples of approved drugs discovered through FBDD validate the approach. However, FBDD still faces numerous challenges.

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Fragment-based drug discovery (FBDD) is a very effective hit identification method. However, the evolution of fragment hits into suitable leads remains challenging and largely artisanal. Fragment evolution is often scaffold-centric, meaning that its outcome depends crucially on the chemical structure of the starting fragment.

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