Epidemiologic and laboratory surveillance of the measles outbreak in the Federation of Bosnia and Herzegovina, February 2014-April 2015.

A measles outbreak with two epidemic waves involving 4649 probable and laboratory-confirmed cases was recorded in six out of ten cantons of the Federation of Bosnia and Herzegovina between February 2014 and April 2015. The majority of the patients had never received measles vaccination (3115/4649, 67.00%), and the vaccination status of another 23% was unknown (1066/4649).

Tumor necrosis factor-alpha serum level in assessment of disease activity in inflammatory bowel diseases.

Aim: To investigate an influence of the concentration of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) in serum on the activity of inflammatory bowel disease (IBD).

Methods: The IBD patients of both genders (n=60) were divided in two equal groups, ulcerative colitis (UC) and Crohn's disease (CD). Based on the result of activity index each group was subdivided in two subgroups: active and inactive phase of the disease.

Nitric oxide as a potential biomarker in inflammatory bowel disease.

The aim of this study was to investigate changes in serum nitric oxide (NO) concentration in inflammatory bowel diseases (IBD) patients and its use as potential biomarker in differential diagnosis of ulcerative colitis (UC) and Crohn's disease (CD) and in disease activity assessment. In 60 patients of both genders - 30 with ulcerative colitis and 30 with Crohn's disease - and 30 controls serum nitric oxide concentration was determined by measuring nitrite concentration, a stable metabolic product of NO with oxygen. Conversion of nitrates (NO3-) to nitrites (NO2-) was done with elementary zinc.

An outbreak of rubella in the Federation of Bosnia and Herzegovina between December 2009 and May 2010 indicates failure to vaccinate during wartime (1992-1995).

A rubella outbreak involving 1900 cases was recorded in the Federation of Bosnia and Herzegovina between mid-December 2009 and the end of May 2010. Sera from 389 suspected rubella cases were examined for the presence of rubella-specific IgM and IgG antibodies. A total of 32 throat swabs from suspected rubella cases were tested by RT-PCR and were used to attempt virus isolation.

A serosurvey reveals Bosnia and Herzegovina as a Europe's hotspot in hantavirus seroprevalence.

The extent of hantavirus seroprevalence in the healthy population from Bosnia and Herzegovina has not yet been investigated; therefore, the aim of this study was to assess the hantavirus seroprevalence in the population from different regions of Bosnia and Herzegovina and in different risk groups. The serosurvey included 1331 subjects from endemic and non-endemic regions in Bosnia and Herzegovina. All sera samples were examined using IgG ELISA, and Western blot (Bunyavirus IgG) tests.

[Diagnosis of chlamydial infections--personal experience].

Objectives: In this paper we evaluated the difference of analytic sensitivity, specificity and predictive values using immunoassays based on antigen detection of Chlamydia trachomatis (Ct) in endocervical swab specimens.

Patients And Methods: 120 fertile female patients were tested for the presence of Ct in the endocervix during two years. The patients represented two risk groups: moderate risk, and low risk group.

Clinical research of dental erosion.

On the base of performed clinical studies of a possible appearance of dental erosion in patients, it can be concluded as follows: 1) Out of 710 treated patients, in 62 is found the appearance of erosive changes of dental tissues. 2) Erosive changes were more prevalent in patients in the third age group, more often in male than in female. 3) Patients with erosive changes are with distinctive gastrointestinal disorders, they used the hard toothbrush, soft food, and in most of them is noticed the appearance of psychic disorders with the aggressive behaving.

[Morphologic changes in the pulp and surrounding structures of the teeth in irradiated animals].

Several animals of the same breed (11 swine-white Landrace) were used in the research. Irradiation was made by radiation from the linear accelerator with lethal doses (3,68-4, 48 Gy). The changes on incisors and molars in the perished animals were observed as well as the changes on the surrounding structures of teeth.

Prognostic value of some parameters of cellular immunity in breast cancer patients.

In 45 histologically verified breast cancer patients the cell-mediated immune responses were tested prior to surgical therapy. The cell immunity was assessed by the percentage of T and active T-lymphocytes and by measuring the lymphocyte reactivity to phytohemagglutin (PHA) and concanavalin A (Con A). Disease-free interval was longer and the mortality after 3, 5 and 8-year follow-up significantly lower in the group of patients with the normal number of T and active T-lymphocytes than in the group of patients with the lower number of those cells.

[Histologic picture of dental pulp in dogs treated with ZnOOK paste].

The activity of zinc-oxide paste on histologic changes of the pulp was examined while the indirect capping of the exposed dog tooth pulp was performed. The results showed that the histologic changes observed in dog tooth pulp were accompanied with hyperaemia and blood vessel dilatation then with the pulp oedema, slight disorder of odontoblast palisade and the presence of the traces of occurrence of tertiary dentin.

[Rotaviruses--causes of minor epidemics of diarrheal diseases in the neonatal department of the Pediatric Clinic in Sarajevo].

A rotavirus epidemic took place at the above mentioned department (8. V 1987 until 19. VI 1987).

[Comparison of the immunoenzyme test (ELISA) with other methods in the detection of rheumatoid factor].

IgM rheumatoid factor was detected, beside ELISA test, by Waaler-Rose, Latex agglutination and indirect immunofluorescent test. 107 patients hospitalized in the Clinic for heart diseases and rheumatism, as well as 50 healthy subjects were examined. In the first group were 50 patients with RA, 30 patients with other rheumatic diseases and 27 with nonrheumatic diseases.