[Clinical and diagnostic value of prostaglandins E determination in patients with ulcer].

The authors investigate the relevance of ulcer clinical variants (recent ulcer, of 10 years history and 2-3 annual exacerbations, chronic ulcer with aggravations and incomplete remissions) to production of endogenic PGE by gastric mucosa and to blood PGE level. It is shown that with ulcer progression PGE synthesis activization is replaced by its inhibition. A reverse relationship appeared between gastric juice and blood PGE and duration of ulcer.

[Prognostic significance of Helicobacter pylori isolation in patients with peptic ulcer].

The author shows that persistent contamination of the mucosa in ulcer patients noticeable even after ulcer healing with Helicobacter pylori leads to disordered coordination of energetic processes in immunocompetent cells. The reserve pathway becomes more active than basic pathway of oxidation, this combining with lymphocyte sensitization to the mucosal tissue. An unfavourable prognostic implication is given to a 1.

[Dynamics of prostaglandin E content in patients with duodenal ulcer various treatment regimens].

PGE levels were measured in duodenal ulcer patients treated by H2-blockers of histamine receptors of hyperbaric oxygenation (HBO). Histadyl is shown to cause a marked decrease in gastric juice PGE concentrations in contrast to HBO that raised PGE levels close to normal values. It is thought necessary to administer long-term maintenance therapy after cicatrisation of the ulcer lesion with the drugs improving local microcirculation and stimulating bicarbonates production in gastric mucosa, synthetic prostaglandins analogues, in particular.

[Prognostic significance of cytochemical tests in peptic ulcer].

The paper is concerned with evaluation of the activity of the intracellular enzymes of lymphocytes--succinate dehydrogenase and alpha-glycerophosphate dehydrogenase of mitochondria, in patients with peptic ulcer running a different course to define their importance in the disease prediction. Aggravation of peptic ulcer was found to result at first in marked activation of lymphocyte energy supply including that at the expense of the formation of new cellular populations. Later the count of lymphocytes with a high enzymatic activity was found to decline together with a reduction of enzymatic activity.

[Cytochemical characteristics of lymphocytes in peptic ulcer under various states of acid secreting function of the stomach].

Metabolic activity of lymphocytes was evaluated in ulcer patients with different acid-production function. Measurement of succinic dehydrogenase and alpha-glycerophosphate dehydrogenase of the mitochondria showed that acid production activity brought about variations in the activity of alpha-glycerophosphate dehydrogenase suggesting activation of a reserve path of the cell energy supply. The data obtained on the strain of the local defence and repair processes in gastric mucosa of patients with ulcer running with hyperacidity especially upon cicatrization of the lesion, provide a basis for the disease outcome.