Cell Death Mechanism of Organometallic Ruthenium(II) and Iridium(III) Arene Complexes on HepG2 and Vero Cells.

Due to side effects and toxicity associated with platinum-derived metal-based drugs, extensive research has been conducted on ruthenium (Ru) complexes. We aim to synthesize a highly oil soluble Ru(II)--cymene complex () with an aliphatic chain group, a bimetallic Ru(II)--cymene complex () with N,S,S triple-coordination and a bimetallic Ir(III)-pentamethylcyclopentadienyl complex () with S,S double-coordination. Subsequently, we investigate the effects of these complexes on Vero and HepG2 cell lines, focusing on cell death mechanisms.

Cellulose based biopolymer nanoscaffold: A possible biomedical applications.

In this work, a combination of cellulose nanofiber (CNF), coffee beans powder (CBP), and reduced graphene oxide (rGO) are used to design a nanowound dressing sheet (Nano-WDS), by vacuum pressure, for their sustained application in wound healing. Nano-WDS was analysed for its mechanical, antimicrobial, biocompatibility, etc., The Nano-WDS had favourable results of the tensile strength (12.

-Alkylation and -Methylation of Amines with Alcohols Catalyzed by Nitrile-Substituted NHC-Ir(III) and NHC-Ru(II) Complexes.

A series of nitrile-modified -heterocyclic carbene (NHC) complexes of Ir(III) (-) and Ru(II) (-) have been prepared by transmetallation of [IrCp*Cl] and [RuCl(-cymene)] forming an NHC-Ag complex. The structures of all complexes were characterized by H NMR, C NMR, and Fourier transform infrared (FT-IR) spectroscopies. And the structures were clearly elucidated by performing X-ray diffraction studies on , , and single crystals.

Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach.

Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials.

Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT).

Functionalized electrospun nanofibers for high efficiency removal of particulate matter.

In recent years, introducing electrospun airfilters to enhance the removal of PM and PM has received much interest. In this study, a novel poly-(vinyl) alcohol (PVA)/carbon nanoparticle (CNP)/tea leaf extract (TLE), functionalized nanofibrous air filter (FNA) was fabricated using an electrospinning method. Novelty of the unique work in the blending of CNP and TLE, first of its kind, for the preparation of FNA.

C(acyl)-C(sp) and C(sp)-C(sp) Suzuki-Miyaura cross-coupling reactions using nitrile-functionalized NHC palladium complexes.

Application of N-heterocyclic carbene (NHC) palladium complexes has been successful for the modulation of C-C coupling reactions. For this purpose, a series of azolium salts (1a-f) including benzothiazolium, benzimidazolium, and imidazolium, bearing a CN-substituted benzyl moiety, and their (NHC)PdBr (2a-c) and PEPPSI-type palladium (3b-f) complexes have been systematically prepared to catalyse acylative Suzuki-Miyaura coupling reaction of acyl chlorides with arylboronic acids to form benzophenone derivatives in the presence of potassium carbonate as a base and to catalyse the traditional Suzuki-Miyaura coupling reaction of bromobenzene with arylboronic acids to form biaryls. All the synthesized compounds were fully characterized by Fourier Transform Infrared (FTIR), and H and C NMR spectroscopies.

Curcumin nanoparticles supported gelatin-collagen scaffold: Preparation, characterization, and study.

It is possible to reveal the potential of water-insoluble drugs by increasing their solubility in water with some nanotechnology techniques. Nanosuspension technology can solve this problem by increasing the water solubility and as well as bioavailability of these drugs. The present work is pointed at the evaluation of nanosuspension of curcumin, a poorly water-soluble drug.

C-C coupling formation using nitron complexes.

A series of RuII (1), RhIII (2), IrIII (3, 4), IrI (5) and PdII (6-9) complexes of the 'instant carbene' nitron were prepared and characterized by 1H- and 13C-NMR, FT-IR and elemental analysis. The molecular structures of complexes 1-4 and 6 were determined by X-ray diffraction studies. The catalytic activity of the complexes (1-9) was evaluated in alpha(α)-alkylation reactions of ketones with alcohol via the borrowing hydrogen strategy under mild conditions.

Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes.

A series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru) were prepared and fully characterized by H, C, F, and P NMR spectroscopy and elemental analysis. The crystal structure of the bimetallic complex (Ru) was determined by X-ray crystallography. Monometallic analogues (Ru) were synthesized to investigate the contributions of ruthenium and the other organic groups (aren, ethylenediamine, butyl) to the activity.