[Decontamination of freshly caught fish infected with Opisthorchis metacercariae by fast electron irradiation].

An experiment that decontaminated of opistorchide metacercariae-infected fish is described. Decontamination was accomplished by fast electron radiation on an ILU-6 accelerator. A high larval mortality (about 98-100%) was shown in the biological control invasions of the experiment animals exposed to radiation in different doses from 1.

[Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias].

Regulation of intracellular calcium homeostasis by means of secondary mediators calmodulin and 4,5-inositol phosphates (products of phosphatidyl inositol hydrolysis) was studied in children with ectopic forms of arrhythmias. Alterations in the system calmodulin-Ca2+ and the activity of phosphoinosite metabolism correlated highly with clinical manifestations of the arrhythmias. The data obtained suggest that a number of molecular mechanisms and responsible for arrhythmias were realized in cell membranes and depended on a complex of intracellular messengers affected within various steps of the hormonal signal transmission.

[Disorders of membrane mechanisms for regulating calcium homeostasis in cardiac arrhythmias in children].

Importance of calmodulin and Ca2+ in membranes of erythrocytes and myocardium was studied in children with ectopic forms of cardiac arrhythmia--extrasystole, paroxysmal and nonparoxysmal tachycardia. Activation of lipid peroxidation and shifts in cytomembrane phospholipid spectrum were shown to be involved in impairments of calcium homeostasis regulation, which is responsible for control of electromechanical parameters and may be related to deterioration of myocardial electrophysiological properties.

[Disorders of membrane mechanisms in stressor damage to the heart in rats of various strains].

The resistance of the rat's organism to emotional stress is determined by alterations of the heart's electric stability. The condition of lipid oxidation is accompanied by alterations of cholesterol and ionised calcium concentrations. Such alterations were expressed in Fisher rats to a greater extent.

[ECG changes in hypertrophic cardiomyopathy in children (data of routine and circadian ECG)].

Analysis is made of the routine and circadian ECG in 32 children with hypertrophic cardiomyopathy. The signs of myocardial hypertrophy of some or other parts of the heart were discovered in 29 children (90.6%).

[Clinico-morphological comparison in children with infectious endocarditis].

As many as 21 children suffering from infectious endocarditis (IE) were examined for the clinical and morphological picture of the disease. The patients' age ranged from 2 to 15 years. In 15 children, IE developed in association with different congenital diseases; in one patient, in the presence of rheumatic heart disease, and in 5 patients, in unaffected heart valves.

[Status of the liver in children with cardiomyopathies (data from echographic study)].

In order to estimate the liver status and hemodynamics in children with non-rheumatic cardiomyopathies, 130 schoolchildren were examined. Of these, 60 children were diagnosed to have hypertrophic and 70 dilated cardiomyopathy. In both cardiomyopathy varieties, alterations in the liver were established to be of secondary character and associated with greater circulation abnormalities.

[Arrhythmia in children with dilated cardiomyopathy (data of 24-hour ECG monitoring)].

The authors demonstrate potentialities of long-term ECG monitoring in the diagnosis of heart rhythm and conduction disturbances in children with dilated cardiomyopathy. Provide the results of comparative studies of routine and 24-hour ECG monitoring in children with dilated cardiomyopathy under every-day life conditions. Show that during 24-hour ECG monitoring, all the children with the above pathology manifest heart rhythm and conduction disturbances of varying intensity and prognostic significance.

[Morphofunctional state of the heart in dilated cardiomyopathy in children].

To study the morphofunctional state of the heart, 49 children aged 1 to 15 years with dilated cardiomyopathy (DCMP) were examined. The diagnosis was established on the basis of comprehensive clinical and instrumental examinations. It was discovered as a result of echocardiography that children with dilated cardiomyopathy show considerable dilatation of the cardiac chambers, accompanied by moderate hypertrophy of the myocardium (mainly of the left ventricle) and by appreciable impairment of the function of myocardial contraction and relaxation together with derangement of heart pump function.

[Ultrasonic methods of diagnosing infectious endocarditis in children].

Ultrasound research methods were applied in 32 children with the clinical signs of infectious endocarditis (IE). The patients' age varied from 3 to 16 years. In 5 patients, IE turned out primary in the intact valves whereas in 27 patients, it superadded on different congenital heart disease.