Publications by authors named "Serap Yagcı"
Article Synopsis
- Cefiderocol is effective against carbapenem-resistant bacteria, but its susceptibility varies based on different interpretive criteria from EUCAST and CLSI.
- Researchers tested 254 CRK blood isolates and found significant differences in resistance rates to cefiderocol when applying EUCAST versus CLSI criteria.
- High cefiderocol resistance rates were especially noted among NDM producers using EUCAST guidelines, leading to the recommendation that these criteria should be prioritized for testing until more clinical data is available.
Article Synopsis
- Aminoglycosides are important for treating infections caused by carbapenemase-producing bacteria (CPK), but resistance to these antibiotics is rising, primarily due to 16S rRNA methyltransferases (RMTs) often found alongside NDM genes.
- In a study of 181 invasive CPK isolates, 60% were resistant to amikacin, gentamicin, and tobramycin, with most of the resistant isolates carrying RMTs, particularly ArmA and RmtC.
- The study found that the resistance is largely linked to specific clonal types, particularly ST2096 and ST14, which are associated with certain carbapenemases and other resistance genes, suggesting that clonal spread is a
Article Synopsis
- - The study evaluated the effectiveness of multiplex real-time polymerase chain reaction (RtPCR) in diagnosing sepsis from whole blood and blood cultures in ICU patients, comparing it to traditional methods over a period from November 2019 to August 2020.
- - Out of 90 patients in the study, 73 had already received antibiotics, and the conventional blood culture was set as the gold standard, revealing varied effectiveness of RtPCR based on the sample type: sensitivity ranged from 11.67% to 89.58% for whole blood and blood culture respectively.
- - The results showed that while RtPCR from blood culture bottles had higher sensitivity and quicker reporting times than traditional methods, it also exhibited a lower specificity compared to Rt
Ceftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMérieux, Marcyl'Étoile, France), 10/4 μg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC was 2/>16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers.
View Article and Find Full Text PDFA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited.
View Article and Find Full Text PDFEarly reporting of the antibiotic susceptibility testing (AST) results is essential for the survival of sepsis patients. In 2019, European Committee on Antimicrobial Susceptibility Testing (EUCAST) published a proposal to detect antimicrobial susceptibility from positive blood culture bottles with a rapid antimicrobial susceptibility test (RAST) method in a maximum of eight hours. In this study, it was aimed to evaluate the EUCAST RAST method in blood culture bottles that resulted with positive signal in BacT/ALERT (bioMérieux, France) blood culture system and that showed gram-negative bacteria with single morphology with Gram stain.
View Article and Find Full Text PDFBackground: Mediastinitis due to Acinetobacter baumannii is rare.
Methods: We report a case of mediastinitis caused by pan-resistant A. baumannii in a patient with multiple comorbidities who underwent cardiopulmonary bypass and we also present a literature review.