Publications by authors named "Seraina Cooksley-Decasper"
Article Synopsis
- Researchers identified fatty acid-binding protein 4 (FABP4) as a potential blood biomarker for assessing coronary artery disease and acute coronary syndrome (ACS) through various data integration methods.
- FABP4 levels were found to be higher in patients experiencing ST-segment-elevation myocardial infarction compared to healthy controls, and elevated levels were linked to increased risk of serious cardiovascular events within 30 days.
- The study suggests that measuring circulating FABP4 could help doctors better stratify risk in ACS patients, though it showed no significant difference in asymptomatic individuals over a 5-year period.
To date, no plaque-derived blood biomarker is available to allow diagnosis, prognosis or monitoring of atherosclerotic vascular diseases. In this study, specimens of thrombendarterectomy material from carotid and iliac arteries were incubated in protein-free medium to obtain plaque and control secretomes for subsequent subtractive phage display. The selection of nine plaque secretome-specific antibodies and the analysis of their immunopurified antigens by mass spectrometry led to the identification of 22 proteins.
View Article and Find Full Text PDFNitrotyrosine is a posttranslational protein modification that occurs under oxidative and nitrosative stress, and plays an important role in numerous pathological conditions. To analyse nitrotyrosine formation several commercial monoclonal and polyclonal antibodies reacting with 3-nitrotyrosine have been developed which however do not work properly in all required assays. Here, antibody phage display was used to select recombinant antibodies that specifically react with nitrotyrosine in various protein contexts.
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