Publications by authors named "Serafim Florentino Neto"
Nanocapsules provide selective delivery and increase the bioavailability of bioactive compounds. In this study, we examined the anticancer and immunomodulatory potential of (crajiru) extract encapsulated in nanocapsules targeting myeloid leukemias. Nanocapsules containing crajiru (nanocapsules-CRJ) were prepared via interfacial polymer deposition and solvent displacement.
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- The kernel oil from Attalea phalerata, or Acurí, has traditional uses in treating respiratory issues, inflammation, and fever, but lacks pharmaceutical research.
- A study developed Acurí oil-loaded nanocapsules, assessing their cytotoxicity, anti-inflammatory effects, and oral toxicity in rats, showing promising results such as high encapsulation efficiency and stability.
- The nanocapsules provided significant anti-inflammatory and antiproliferative effects against cancer cells while being nontoxic, indicating potential for new antitumor therapies and nutraceutical applications.
Introduction: Amyrins are triterpenes that have attractive pharmacological potential; however, their low water solubility and erratic stomach absorption hinders their use as a drug. The aim of this paper was to develop a novel α-amyrin-loaded nanocapsule for intestinal delivery and evaluate, preliminarily, its cytotoxic ability against leukemic cells.
Material And Methods: Five nanocapsule formulations were designed by the solvent displacement-evaporation method.