Publications by authors named "Serafettin Kartal"
J Vet Pharmacol Ther
January 2025
Article Synopsis
- The study aimed to examine how the pharmacokinetics of marbofloxacin varies with the age of calves after a single IV dose of 10 mg/kg.
- It involved Montofon calves of different ages (1, 2, and 4 months), measuring plasma concentrations and calculating pharmacokinetic parameters like half-life, volume of distribution, total clearance, and area under the curve (AUC) using HPLC.
- Findings indicated that as calves age, the elimination half-life and AUC decrease while total clearance increases, suggesting that the effectiveness of marbofloxacin may decline with age, calling for a reevaluation of the dosing strategy based on the bacteria's minimum inhibitory concentration (MIC) values.
