Furan-Conjugated Tripeptides as Potent Antitumor Drugs.

Cervical cancer is among the leading causes of death in women. Chemotherapy options available for cervical cancer include highly cytotoxic drugs such as taxol, cisplatin, 5-florouracil, and doxorubicin, which are not specific. In the current study, we have identified a new peptide conjugate (Fur-2-Nal-Ala-Phe-CONH) (conjugate ), from screening of a small library of tripeptide-conjugates of furan, as highly potent anticancer compound against human cervical cancer cells (HeLa cells) (IC = 0.

Potent leishmanicidal and antibacterial metabolites from .

Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan () and a known compound (+)- cycloolivil (). The structures of and were determined by various spectroscopic techniques and were assayed for their antibacterial and leishmanicidal potential. Compound showed 75% inhibition after 24 h of incubation and 98% inhibition after 48 h of incubation against KWH23 promastigotes at 100 μg/mL concentration, while compound exhibited 73% and 96% inhibition at the same concentration and incubation time.