Publications by authors named "Ser Ling Chua"
Importance: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment.
Objective: To reach an international, Delphi-based multinational expert consensus on the diagnostic workup, severity assessment, and treatment of patients with DRESS.
Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction.
Objective: To explore treatment approaches across Europe and their impact on the disease course, as well as prognostic factors and culprit drugs.
Methods: In this retrospective European multicentric study, we included patients with probable or certain DRESS (RegiSCAR score ≥ 4) between January 2016 and December 2020.
Article Synopsis
- - This study analyzed severe blistering skin reactions caused by immune checkpoint inhibitors (ICI) in 32 patients, emphasizing that such reactions, although rare, can be life-threatening and are often misdiagnosed as epidermal necrolysis (EN).
- - The research found that symptoms like fever, ocular involvement, and extensive skin detachment were more common in patients diagnosed with EN compared to those with lichenoid dermatosis (LD) or unclassified dermatosis (UD), highlighting the need for careful diagnostic review.
- - Treatment usually involved corticosteroids, and 25% of patients died during the acute phase; however, most did not restart the ICI, suggesting a potential issue with management approaches that need further consensus and clarity
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious drug reactions that can lead to high mortality rates, and there’s no agreed-upon treatment plan across Europe.
- * A retrospective study involving 212 adults aimed to identify treatment methods, risk factors, and outcomes for patients with SJS/TEN in 13 centers from 2015 to 2019, revealing that most patients had identified culprit drugs, primarily antibiotics and anticonvulsants.
- * The findings showed that 63.7% of patients experienced severe complications, with a 20.8% mortality rate within 6 weeks, and significant body surface area detachment was linked to more severe outcomes.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterised by recurrent painful boils in flexural sites, such as the axillae and groin, that affects about 1% of the population, with onset in early adulthood.
Objectives: To assess the effects of interventions for HS in people of all ages.
Search Methods: We searched the following databases up to 13 August 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 7, 2015), MEDLINE (from 1946), EMBASE (from 1974), and LILACS (from 1982).
Background: Health-related quality of life instruments are typically developed and validated for use in developed countries by patients who can read and write. Little is known about the feasibility of using adaptations of validated instruments in situations where literacy rates are low.
Objective: We aimed to translate, culturally adapt, and test an oral version of Skindex-16 in Runyankore, the predominant language in Mbarara, Uganda, for use in dermatologic research.