Metal-organic frameworks in separations: A review.

It is possible to design high permeability and selective metal-organic frameworks (MOFs) with designable functionality. The large number of possible MOF structural permutations arise from the considerable number of possible metal nodes and the great variety of organic ligands used for these materials. Herein, we discuss the applications of MOFs in all manner of separations including gas adsorption/separations, membranes, gas chromatography (GC), liquid chromatography (LC), water harvesting and the computer/machine learning design of MOFs.

Liquid chromatography enantiomeric separation of chiral ethanolamine substituted compounds.

Eleven racemic ethanolamine derivatives were prepared, and their enantiomers were separated using liquid chromatography with various chiral columns. These derivatives included chiral vicinal amino alcohols, β-hydroxy ureas, β-hydroxy thioureas, and β-hydroxy guanidines, all of which are present in many active pharmaceutical ingredients. The screening study was performed with six chiral stationary phase containing columns, including four recently introduced superficially porous particles bonded with two macrocyclic glycopeptides, a cyclodextrin derivative and a cyclofructan derivative.

High efficiency functionalized hydrophilic cyclofructans as stationary phases in sub/supercritical fluid chromatography.

Packed column SFC has become very popular for preparative and analytical separations due to the low cost of CO, its accessible critical temperature, and pressure, with the additional benefit of a low environmental burden. Currently, there is a shortage of new polar stationary phase chemistries for SFC. In this work, two new functionalized cyclofructan columns are introduced and evaluated for their performance in achiral SFC separations for the first time.

Enhancing supercritical fluid chromatographic efficiency: Predicting effects of small aqueous additives.

Supercritical fluid chromatography is becoming more prevalent, particularly in industry. This is due to the inexpensive, and more importantly, environmentally benign carbon dioxide that is used as the major component of the mobile phase. Water is minimally miscible with carbon dioxide at temperatures and pressures commonly used in SFC.