Publications by authors named "Sepideh Ganjalikhan Hakemi"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain cancer, prompting the study of U87 cells in wild-type rats to explore a natural model for better understanding its behavior.
- The research involved implanting GBM cells in rats and monitoring tumor development and immune response at designated intervals, revealing significant immune cell infiltration over time.
- Findings indicated that the immune system's activation against GBM tumors is time-dependent, resulting in tumor regression by the sixth week due to immune reactions.
Administration of adipose-derived mesenchymal stem cell conditioned medium improves ovarian function in polycystic ovary syndrome rats: involvement of epigenetic modifiers system.
J Ovarian Res
December 2023
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a complex condition influenced by various genetic, hormonal, and environmental factors that impacts women's reproductive health.
- The study investigated how adipose-derived mesenchymal stem cells (ASC) and their conditioned medium (ASC-CM) affect epigenetic regulators, steroid hormone function, and follicle development in rats with letrozole-induced PCOS.
- Administration of ASC-CM improved several symptoms of PCOS in the rats, including metabolic disorders and reproductive dysfunction, as indicated by better glucose tolerance, regular estrus cycles, and reduced ovary dimensions and body weight.
Aims: this study aimed to examine the protective role of omega-3 and insulin on reproductive system of the male mouse model of type II diabetes mellitus (T2DM), especially DNA integrity and chromatin quality.
Main Methods: adult age-matched mice were divided into intact, sham, or T2DM groups (n = 7) which received a high-fat diet/low-dose streptozotocin. T2DM-induced animals underwent no treatment as diabetic control (T2DM), received omega-3 (T2DM + Omg3), received insulin (T2DM + Ins) and their combination (T2DM + Omg3 + Ins) for 35 days.
Introduction: In the current study, we investigate whether oral administration of agmatine (AGM) could effectively reduce motor and cognitive deficits induced by bile duct ligation (BDL) in an animal model of hepatic encephalopathy (HE) through neuroprotective mechanisms.
Methods: The Wistar rats were divided into four groups: sham, BDL, BDL+ 40 mg/kg AGM, and BDL+ 80 mg/kg AGM. The BDL rats were treated with AGM from 2 weeks after the surgery for 4 consecutive weeks.
It is well established that maternal lifestyle during pregnancy and lactation affects the intrauterine programming of F1 offspring. However, despite the co-use of alcohol and nicotine is a common habit, the effects of exposure to both substances on the reproductive system of F1 male offspring and the underlying mechanisms of developmental programming have not been investigated. The present study aimed to examine pre- and postnatal concurrent exposure to these substances on genetic and epigenetic alterations of sperm cells as well as testis properties of F1 offspring compared with exposure to each substance alone.
View Article and Find Full Text PDFBackground: Busulfan (BU) has a destructive effect on the male reproductive system. The goal of this study was to assess the effects of olive leaf extract (OLE) as a source of antioxidants and phenolic compounds, on BU-induced damages in rat testes.
Materials And Methods: In this experimental study, 40 male Wistar rats were randomly divided into 5 groups.