The effect of anterior tab flap technique on graft success rate in large tympanic membrane perforation.

Purpose: Questions have been raised about the effectiveness of myringoplasty techniques for the large tympanic membrane perforation. Various surgical approaches have been recommended to achieve a satisfactory graft success rate in large tympanic membrane perforations. Consequently, there is a growing body of literature that recognizes this controversial topic in otology.

Bruck syndrome - a rare syndrome of bone fragility and joint contracture and novel homozygous FKBP10 mutation.

Bruck syndrome is an autosomal recessive syndrome consisting of bone fragility and congenital joint contractures. According to the genotype, it has been classified into types 1 and 2. Recently, mutations in FKBP10, localised to chromosome 17q21, have been identified in some patients of Bruck syndrome.