Publications by authors named "Sepehr Safdel"
Article Synopsis
- - The study investigates how leptin, an immune-regulating hormone, affects dendritic cells (DCs) to promote TH1 cell differentiation and IL-12 production while reducing IL-10 production, particularly in a breast cancer model in mice.
- - Mice with tumors were treated with various DC vaccines (pretreatment with leptin, LPS, or both) and showed that the combination (Leptin/LPS) significantly increased cytotoxic T lymphocytes and TH1 cell frequencies while enhancing key immune markers and reducing tumor growth.
- - The findings suggest that the Leptin/LPS DC vaccine is more effective than individual treatments at inhibiting breast cancer development and enhancing the body's immune response against the tumor.
Purpose: Prostaglandin E2 (PGE2), a product of cyclooxygenase (COX) pathway of arachidonic acid, exerts inhibitory impacts on dendritic cell (DC) activity to repress anti-tumor immune responses. Therefore, targeting COX during DC vaccine generation may enhance DC-mediated antitumor responses. We aimed to investigate the impacts of DC vaccine treated with celecoxib (CXB), a selective COX2 inhibitor, on some T cell-related parameters.
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