A universal calibration framework for mixed-reality assisted surgery.

Background: Mixed-reality-assisted surgery has become increasingly prominent, offering real-time 3D visualization of target anatomy such as tumors. These systems facilitate translating preoperative 3D surgical plans to the patient's body intraoperatively and allow for interactive modifications based on the patient's real-time conditions. However, achieving sub-millimetre accuracy in mixed-reality (MR) visualization and interaction is crucial to mitigate device-related risks and enhance surgical precision.