Publications by authors named "Seonyeong An"
Achieving fast and secure wound closure without ocular foreign body sensation is highly desired in ophthalmologic surgery. Sutureless approaches using tissue adhesives are gaining popularity, but their practical use is limited by the difficulty in controlling adhesion time and satisfying safety standards without compromising adhesive performance. Herein, we report user-demand hydrogel-forming ocular glues based on multilength photo-crosslinkable hyaluronic acid (HA), achieving firm tissue adhesion under wet and dynamic conditions and possessing cornea-like optical transparency.
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- Smallpox, caused by the variola virus, is typically vaccinated using a bifurcated needle that punctures the skin, but this method requires skill and specific storage conditions for the live vaccine.
- Researchers have developed a microneedle patch coated with a live vaccinia virus in a hyaluronic acid solution, allowing for easier and more accurate transdermal vaccination while maintaining the vaccine's effectiveness.
- Testing on mice showed that this new method increased immune responses and demonstrated improved viral stability during storage, showcasing it as a promising alternative for smallpox vaccination.
Article Synopsis
- Cryopreservation is becoming increasingly important for cell storage in research, with DMSO often used as a cryoprotectant to enhance cell survival during freezing.* -
- The study introduces biodegradable hyaluronic acids (HAs) to reduce DMSO use in cryopreservation, resulting in higher cell viability and proliferation after thawing.* -
- Despite not altering ice crystal size, HAs decrease the apoptosis-related Ras/Rho signaling pathway, suggesting potential for safer cryoprotectants in clinical applications.*