A Multiscale Geospatial Dataset and an Interactive Visualization Dashboard for Computational Epidemiology and Open Scientific Research.

The coronavirus disease (COVID-19) continued to strike as a highly infectious and fast-spreading disease in 2020 and 2021. As the research community actively responded to this pandemic, we saw the release of many COVID-19-related datasets and visualization dashboards. However, existing resources are insufficient to support multiscale and multifaceted modeling or simulation, which is suggested to be important by the computational epidemiology literature.

Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases.

The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-subunit complex is also pivotal for clearance of harmful proteins that are produced throughout the lifetime of eukaryotes. Recent structural and kinetic studies have revealed a multitude of conformational states of the proteasome in substrate-free and substrate-engaged forms.

Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets.

Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often limited by recurring drug resistance. More importantly, not all molecular targets are enzymes or receptors with druggable 'hot spots' that can be directly occupied by active site-directed inhibitors.