Publications by authors named "SeongHoon Jo"
Hydrogels are promising materials for biomedical applications, particularly in drug delivery and tissue engineering. This study highlights thermoresponsive hydrogels, specifically poly(lactic--glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA triblock copolymers, and introduces a feed rate-controlled polymerization (FRCP) method. By utilizing an organic catalyst and regulating the monomer feed rate, the sequence distribution of PLGA within the triblock copolymer is controlled.
View Article and Find Full Text PDFPhotothermal therapy (PTT) at mild temperatures ranging from 44 to 45 °C holds tremendous promise as a strategy for inducing potent immunogenic cell death (ICD) within tumor tissues, which can reverse the immunosuppressive tumor microenvironment (ITM) into an immune-responsive milieu. However, accurately and precisely controlling the tumor temperature remains a formidable challenge. Here, we report the precision photothermal immunotherapy by using silica-coated gold nanorods (AuNR@SiO), and investigating the optimal administration routes and treatment protocols, which enabled to achieve the sustained and controlled mild heating within the tumor tissues.
View Article and Find Full Text PDFCopper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their applications. In this study, we present Cu-loaded silica nanoparticles fabricated through the chelation of Cu ions by silanol groups.
View Article and Find Full Text PDFHeating nanoparticles with a magnetic field could facilitate selective remote control of neural activity in deep tissue. However, current magnetothermal stimulation approaches are limited to single-channel stimulation. Here, we investigated various designs for multichannel magnetothermal stimulation based on an array of resonant coils that are driven by a single loop coil.
View Article and Find Full Text PDFRecent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment.
ACS Appl Mater Interfaces
January 2023
Article Synopsis
- The blood-brain barrier (BBB) complicates drug delivery and imaging in brain disorders, prompting interest in new methods like ultrasound-mediated nanoparticle delivery.
- Focused ultrasound (FUS) can temporarily open the BBB, allowing for better delivery of therapeutic agents and enhancing photoacoustic brain imaging techniques, which have high resolution and penetration capability.
- The combination of ultrasound and nanoparticles shows promise for improving both the diagnosis and treatment of brain-related conditions through effective visualization and targeted therapy.*
Photothermal therapy (PTT) is one of the most promising cancer treatment methods because hyperthermal effects and immunogenic cell death via PTT are destructive to cancer. However, PTT requires photoabsorbers that absorb near-infrared (NIR) light with deeper penetration depth in the body and effectively convert light into heat. Gold nanoparticles have various unique properties which are suitable for photoabsorbers, e.
View Article and Find Full Text PDFArticle Synopsis
- Lymph node mapping is crucial in cancer immunotherapy as it helps evaluate immune responses, and new theragnostic glycol-chitosan-coated gold nanoparticles (GC-AuNPs) enhance lymph node visibility in ultrasound-guided photoacoustic imaging.
- The engineered OVA-GC-AuNPs effectively deliver tumor antigens to macrophages in lymph nodes, showing strong endocytosis and resulting in robust photoacoustic signals.
- After injecting GC-AuNPs in mice, imaging demonstrates increased accumulation over time in lymph nodes, revealing their potential for improved cancer immunotherapy by presenting tumor antigens to activate immune responses.