Publications by authors named "Seong-il Oh"
Background And Purpose: This study evaluated the diagnostic utility of an anti-signal-recognition particle 54 (anti-SRP54) antibody-based enzyme-linked immunosorbent assay (ELISA) as well as the clinical, serological, and pathological characteristics of patients with SRP immune-mediated necrotizing myopathy (IMNM).
Methods: We evaluated 87 patients with idiopathic inflammatory myopathy and 107 healthy participants between January 2002 and December 2023. The sensitivity and specificity of the ELISA for anti-SRP54 antibodies were assessed, and the clinical profiles of patients with anti-SRP54 antibodies were determined.
Article Synopsis
- Researchers studied the quality of life (QOL) of patients with a condition called MOGAD and compared it to another condition called AQP4-IgG positive NMOSD.
- They found that the overall QOL was similar between both groups, but many patients in both groups struggled with sleep, pain, and feelings of sadness.
- The study suggests that both conditions need more focus on improving sleep and mental health to help patients feel better overall.
Article Synopsis
- A study investigated the impact of the timing of treatment for the first acute attack of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) on long-term relapse risk and conversion to MOG-IgG seronegative status.
- Conducted in South Korea, the research involved a cohort of 240 adults diagnosed with MOGAD, focusing on their treatment timing categorized as early, intermediate, or late.
- Results indicated that 45.8% of patients experienced relapses and 25% converted to seronegative MOG-IgG, highlighting the potential significance of timely treatment in managing MOGAD.
Article Synopsis
- Long COVID significantly impacts patients with preexisting neurological diseases, potentially worsening their conditions and leading to various neurological and mental health symptoms.
- A study involving 85 neurological patients post-COVID-19 revealed that 68% experienced neurological symptoms, with notable rates of anxiety (36.5%), depression (34.1%), and fatigue (42.4%).
- The findings emphasize the necessity for ongoing monitoring and a collaborative treatment strategy for patients dealing with both long COVID effects and existing neurological issues.
Article Synopsis
- Bulbar dysfunction in ALS negatively impacts daily life, causing issues like weight loss and shorter survival rates, with existing evaluation methods lacking Korean-specific tools.* -
- This study developed and validated the Korean version of the Center for Neurologic Study Bulbar Function Scale (K-CNS-BFS) to assess bulbar dysfunction in Korean ALS patients.* -
- The K-CNS-BFS demonstrated strong reliability and validity, effectively measuring bulbar dysfunction and correlating well with established ALS assessments.*
Autophagy is a self-degradation system for recycling to maintain homeostasis. p62/sequestosome-1 (p62) is an autophagy receptor that accumulates in neuroglia in neurodegenerative diseases. The objective of this study was to determine the elevation of plasma p62 protein levels in patients with Charcot-Marie-Tooth disease 1A (CMT1A) for its clinical usefulness to assess disease severity.
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- During the COVID-19 pandemic, patients with myasthenia gravis (MG) faced greater risks, including higher mortality rates compared to the general public due to respiratory issues and immunotherapy.
- A study in South Korea analyzed 92 MG patients who contracted COVID-19, focusing on the differences in clinical outcomes between those vaccinated and unvaccinated.
- Results showed that unvaccinated patients had significantly higher hospitalization rates, ICU admissions, and deterioration of MG compared to vaccinated patients, highlighting the importance of vaccination in this vulnerable population.
Background: Optic neuritis (ON) prognosis is influenced by various factors including attack severity, underlying aetiologies, treatments and consequences of previous episodes. This study, conducted on a large cohort of first ON episodes, aimed to identify unique prognostic factors for each ON subtype, while excluding any potential influence from pre-existing sequelae.
Methods: Patients experiencing their first ON episodes, with complete aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibody testing, and clinical data for applying multiple sclerosis (MS) diagnostic criteria, were enrolled.
Background And Purpose: Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of F-Fluorodeoxyglucose Positron Emission Tomography (F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods: A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of F-FDG PET in dementia.
Background And Aims: Scrub typhus is an endemic disease in the fall season that occurs in a limited number of places known as the Tsutsugamushi Triangle. Peripheral neuropathy is a common complication of scrub typhus. Herein, we encountered several patients with ascending paralysis after scrub typhus infection, who were diagnosed with Guillain-Barré syndrome (GBS).
View Article and Find Full Text PDFBackground And Purpose: Cognitive and behavioral changes are common in amyotrophic lateral sclerosis (ALS), with about 15% of patients presenting with overt frontotemporal dementia and 30%-50% with varying degrees of impairments. We aimed to develop and validate the Korean version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS-K), a brief multidomain assessment tool developed for ALS patients with physical disability.
Methods: We developed the ECAS-K according to the translation guidelines, and administered it to 38 patients with ALS and 26 age- and education-level-matched controls.
Background: Neuromyelitis optica spectrum disorder (NMOSD) causes relapsing inflammatory attacks in the central nervous system, leading to disability. As rituximab, a B-lymphocyte-depleting monoclonal antibody, is an effective in preventing NMOSD relapses, we hypothesised that earlier initiation of rituximab can also reduce long-term disability of patients with NMOSD.
Methods: This multicentre retrospective study involving 19 South Korean referral centres included patients with NMOSD with aquaporin-4 antibodies receiving rituximab treatment.
Article Synopsis
- The study aimed to understand the characteristics of Korean patients with anti-HMGCR myopathy by measuring anti-HMGCR antibodies and analyzing clinical, radiological, and pathological features.
- Among the 99 patients with inflammatory myopathy, 17 tested positive for anti-HMGCR antibodies, many of whom had taken statins, and the most common symptom reported was proximal muscle weakness.
- The findings revealed a higher antibody titer in statin-naïve patients compared to those exposed to statins, and also suggested the presence of other myositis-specific autoantibodies in more than half of the patients.
Background And Purpose: Fingolimod (FTY) inhibits lymphocyte egress from lymphoid organs to cause lymphopenia, but the clinical implications of FTY-induced lymphopenia are not fully understood. We aimed to determine the frequency and severity of lymphopenia during FTY treatment among Korean patients with multiple sclerosis (MS), and its association with infections.
Methods: We retrospectively reviewed the medical records of patients with MS treated using FTY from 12 referral centers in South Korea between March 2013 and June 2021.
Despite recent advances in next-generation sequencing, the underlying etiology of adult-onset leukoencephalopathy has been difficult to elucidate. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a representative hereditary adult-onset leukoencephalopathy associated with vasculopathy. Leukoencephalopathy in spastic paraplegia type 4 (SPG4) is known to be rare, but it might be underestimated because most spastic paraplegia with leukoencephalopathy is rarely considered.
View Article and Find Full Text PDFBackground And Objective: To investigate the clinical relevance of CSF myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) testing in a large multicenter cohort.
Methods: In this multicenter cohort study, paired serum-CSF samples from 474 patients with suspected inflammatory demyelinating disease (IDD) from 11 referral hospitals were included. After serum screening, patients were grouped into seropositive myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD, 31), aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD, 60), other IDDs (217), multiple sclerosis (MS, 45), and non-IDDs (121).
Background And Purpose: The Spinal and Bulbar Muscular Atrophy Functional Rating Scale (SBMAFRS) is a reliable and valid instrument for evaluating the functional status of patients with spinal and bulbar muscular atrophy (SBMA). This study aimed to validate a Korean version of the SBMAFRS in an SBMA population.
Methods: We applied the SBMAFRS to 64 SBMA patients at their regular follow-up clinical visits.
Article Synopsis
- * Out of 586 participants, 36 (6.1%) tested positive for anti-MOG antibodies, while 185 (31.6%) tested positive for anti-AQP4 antibodies.
- * The study revealed that MOG antibody prevalence is about five times lower than AQP4 antibody prevalence among these adults, with no individuals showing both antibodies simultaneously.
Purpose: This study aimed to investigate the current status of bariatric and metabolic surgery in Daejeon and Chungcheong province and to describe the early experiences after public medical insurance coverage in 2019.
Materials And Methods: Between January 2019 and August 2019, 64 cases of bariatric and metabolic surgery were performed in patients with morbid obesity or uncontrolled type 2 diabetes. We prospectively collected and analyzed data regarding the patients' demographics and comorbidities, surgical results, and early complications.