Publications by authors named "Seong-Joon Koh"
Article Synopsis
- Inflammatory bowel disease may lead to a heightened risk of colitis-associated cancer (CAC), which this study investigates using mouse models.
- TLR3 was examined for its role in CAC, showing that TLR3 knockout mice had more severe colitis and a higher tumor burden compared to wild-type mice.
- The study concluded that enhancing TLR3 signaling could potentially serve as a therapeutic strategy to mitigate the development of CAC in patients with inflammatory bowel disease.
Article Synopsis
- Antibiotic usage in early life may influence the risk of inflammatory bowel disease (IBD), with a specific focus on ulcerative colitis among South Korean infants.
- A study involving nearly 3 million infants found that most (87%) used antibiotics within their first year, and this usage was associated with a decreased risk of ulcerative colitis, especially when exposure occurred earlier.
- The findings suggest that specific antibiotics, particularly penicillin, could potentially play a protective role against IBD, with the results remaining consistent after factoring in dietary influences.
Article Synopsis
- The use of NSAIDs for chronic conditions has led to an increase in NSAID-induced enteropathy, creating a need for effective preventive and treatment strategies.
- Tegoprazan was tested on human epithelial cells exposed to indomethacin, showing a significant improvement in cell viability and restoration of tight-junction protein levels, which are crucial for intestinal health.
- The study concluded that tegoprazan protects small intestinal epithelial cells from NSAID-induced damage by enhancing tight junction protein expression and reducing inflammation and cell death.
Background: The effects of childhood obesity or weight gain on the development of early-onset follicular occlusion triad (FOT) among children, which includes hidradenitis suppurativa (HS), acne conglobata (AC), and dissecting cellulitis of the scalp (DCS), remain unknown.
Objectives: To investigate the association between body mass index (BMI) or its changes and early-onset FOT development.
Methods: This nationwide population-based longitudinal cohort study included a cohort of 2,012,928 Korean children who underwent two consecutive health examinations at 30-36 months and 42-48 months of age between 2009 and 2020.
Childhood Obesity, Weight Change, and Pediatric Immune-Mediated Skin Diseases.
J Invest Dermatol
April 2024
Whether childhood obesity or weight gain leads to the development of pediatric immune-mediated skin diseases remains unclear. We aimed to determine the associations between body mass index or body mass index changes and the development of 3 main immune-mediated skin diseases-alopecia areata, atopic dermatitis (AD), and psoriasis-by analyzing a longitudinal cohort of 2,161,900 Korean children from 2009 to 2020. The findings indicated that children who were obese had a higher risk of pediatric immune-mediated skin diseases than those with normal weight (P for trend < .
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- The study developed the Mobile-Centered Digital Health Readiness: Health Literacy and Equity Scale (mDiHERS) to assess digital health readiness among patients, particularly those with chronic conditions like inflammatory bowel disease.
- Conducted from October 2021 to October 2022, the research included literature reviews, focus groups, and validation with 403 participants, confirming the scale's reliability and construct validity through various statistical analyses.
- mDiHERS consists of 36 items across 6 domains, effectively measuring patients' abilities and readiness to engage with digital health services, highlighting both technical skills and confidence in using mobile health technology.
Sepsis has a high mortality rate and leads to multi-organ failure, including lung injury. Inactive rhomboid protease family protein (iRhom2) has been identified as accountable for the release of TNF-α, a crucial mediator in the development of sepsis. This study aimed to evaluate the role of iRhom2 in sepsis and sepsis-induced acute lung injury (ALI).
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- Fever of unknown origin (FUO) poses a significant diagnostic challenge, with some studies linking it to genetic factors like chromosomal abnormalities.
- A female patient with a 4.5 Mb Xp microdeletion experienced recurrent FUO alongside other serious symptoms, leading researchers to investigate her immune response through advanced techniques like single-cell RNA sequencing.
- The findings revealed enhanced populations of certain T cells and inflammatory markers, alongside impaired Treg cell function, suggesting that her unique genetic makeup contributed to her immune system issues and the chronic fever.
Background/aims: The prevalence and incidence of ulcerative colitis (UC) in Korea is increasing. Each patient has a different disease course and treatment response. Recently, with the development of biologic agents, histological remission has become a treatment goal.
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- Inflammatory bowel disease (IBD), once seen primarily in Western countries, is now on the rise in Asia, with notable differences in how it affects populations there compared to the West.
- This study focused on South Korea, analyzing data from 2010 to 2018 to assess new cases, incidence rates, medication trends, and clinical outcomes of Crohn's disease (CD) and ulcerative colitis (UC).
- Results showed that CD incidence has stabilized, while UC rates are increasing, particularly among younger patients, and there has been a shift towards using more modern treatments like immunomodulators and biologics, resulting in improved clinical outcomes over time.*
It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD.
View Article and Find Full Text PDFIntroduction: The chemoattractant receptor, G protein-coupled receptor 15 (GPR15), promotes colon homing of T cells in health and colitis. GPR15 function in colon cancer is largely unexplored, motivating our current studies.
Methods: In human study, immune cells were isolated from tumor tissues and healthy surgical tumor margins (STM), and their proportions as well as expression of GPR15 was analyzed by flow cytometry.
Article Synopsis
- - Psoriasis is a chronic inflammatory condition linked to the activation of the IL-23/IL-17 pathway and may be influenced by the gut-skin connection and intestinal microbiota.
- - Researchers studied the impact of clusterin, a glycoprotein, on psoriatic skin inflammation and related systemic issues in a mouse model, revealing that its absence reduced inflammation and altered gut microbiota composition.
- - High clusterin levels were found in the skin of psoriasis patients, suggesting that inhibiting clusterin could potentially reduce symptoms like skin inflammation and colitis while affecting gut microbiota ratios.
Background/aims: Infectious complications are major concerns when treating patients with inflammatory bowel disease (IBD). This study evaluated clinical differences across countries/regions in the management of infectious diseases in patients with IBD.
Methods: A multinational online questionnaire survey was administered to participants at the 8th meeting of the Asian Organization for Crohn's and Colitis.
Article Synopsis
- - A multicenter study in Korea assessed the effectiveness and safety of adalimumab (ADA) for treating intestinal Behcet's disease (BD) in 67 patients, focusing on outcomes over 52 weeks.
- - Results showed a high survival rate for the drug (83.5%) and significant improvement in disease activity and key blood markers throughout the treatment period.
- - The study concludes that ADA is a promising treatment option for patients with refractory intestinal BD, demonstrating both efficacy and minimal safety issues in real-world settings.
Introduction: Rosacea and inflammatory bowel disease (IBD) are chronic inflammatory disorders of the skin and the gut, which are interfaces between the environment and the human body. Although growing evidence has implicated a possible link between rosacea and IBD, it remains unclear whether IBD increases the risk of rosacea and vice versa. Therefore, we investigated the association between rosacea and IBD in this study.
View Article and Find Full Text PDFInflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a lifelong disease that manifests with chronic intestinal inflammation, sequential fibrosis, and an increased risk of colitis-associated colon cancer (CAC). The combined effects of genetic, immunological, environmental, and microbial factors render it difficult to determine the specific mechanism underlying the induction and perpetuation of IBD. Various animal models of IBD have contributed enormously to the understanding of IBD pathogenesis in terms of genomics, transcriptomics, proteomics, microbiome, and drug development of novel therapeutics.
View Article and Find Full Text PDFChronic colonic inflammation is a feature of cancer and is strongly associated with tumorigenesis, but its underlying molecular mechanisms remain poorly understood. Inflammatory conditions increased ITF2 and p65 expression both ex vivo and in vivo, and ITF2 and p65 showed positive correlations. p65 overexpression stabilized ITF2 protein levels by interfering with the binding of Parkin to ITF2.
View Article and Find Full Text PDFObjectives: There are a few studies about the relationship between inflammatory bowel disease (IBD) and atopic dermatitis (AD). It is implied that both diseases have common pathophysiologic mechanisms and can affect each other. However, little information is available on the effect of AD on the clinical course of patients with IBD.
View Article and Find Full Text PDFBackground: Tofacitinib is a small molecule that inhibits Janus kinase and has been reported to be effective in Western patients with ulcerative colitis (UC). However, the real-life data on tofacitinib in Asian UC patients are limited.
Objective: To investigate the real-life effectiveness and safety of tofacitinib induction and maintenance treatment in Korean patients with UC.
Background: Prevalence of depression and anxiety are known to be increased in patients with inflammatory bowel disease (IBD), but it is unclear whether such elevations adversely affect IBD outcomes.
Objective: We aimed to investigate the association between depression or anxiety and clinical outcomes of IBD.
Method: Using claims data from the South Korean National Health Insurance Service (NHIS), patients with IBD were identified by codes of the International Classification of Disease, 10th Revision (ICD-10) and the Rare/Intractable Disease (RID) registration program for years 2010 to 2017.
Background: The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC.
Objective: We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database.
Methods: FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service.
The prevalence of colorectal neoplasm in patients with non-alcoholic fatty liver disease has increased twice as high as that in the general population. FibroScan is a new modality for evaluating hepatic steatosis. This study aimed to investigate the relationship between the risk of high-risk colorectal neoplasia and hepatic steatosis examined using FibroScan.
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