Single dose of multi-clade virus-like particle vaccine protects chickens against clade 2.3.2.1 and clade 2.3.4.4 highly pathogenic avian influenza viruses.

Virus-like particles (VLPs) are recognized as an alternative vaccine platform that provide effective protection against various highly pathogenic avian influenza viruses (HPAIVs). Here, we developed multi-clade VLPs expressing two HAs (a chimera of clade 2.3.

Major vascular injury during nonvascular surgeries.

Background: Intraoperative vessel injuries can be serious enough to threaten the patient's survival. This study was performed to analyze the pattern, management, and outcome of intraoperative major vessel injuries and to clarify the risk factors leading to the injury.

Methods: From January 2007 to July 2010, patients with intraoperative vessel injuries during nonvascular surgeries that were treated by vascular surgeons at a tertiary referral center were enrolled, and electronic medical records were reviewed retrospectively.

High prevalence of peripheral arterial disease in Korean patients with coronary or cerebrovascular disease.

This prospective study surveyed the prevalence of peripheral arterial disease (PAD) in Korean patients with coronary arterial disease (CAD) or cerebrovascular disorder (CVD). From March 2010, 576 hospitalized patients in cardiovascular or stroke center were enrolled as the study group. Ankle-brachial index (ABI) was measured and the cut-off point for diagnosing PAD was ≤ 0.

A Clinical Comparison of Laparoscopic versus Open Appendectomy for Complicated Appendicitis.

Purpose: Although laparoscopic appendectomies (LAs) are performed universally, a controversy still exists whether the LA is an appropriate surgical approach to complicated appendicitis (CA). We retrospectively evaluated the outcomes of laparoscopic versus open appendectomies for CA.

Methods: We retrospectively analyzed 60 consecutive patients who were diagnosed as having CA from July 2009 to January 2011.

Long-term outcomes after revascularization for advanced popliteal artery entrapment syndrome with segmental arterial occlusion.

Objectives: There are few long-term follow-up studies about the result of revascularization surgery for the treatment of popliteal artery entrapment syndrome (PAES). We performed this retrospective study to analyze the long-term result of revascularization surgery in patients with advanced PAES during the last 16 years.

Methods: Twenty-two limbs in 18 consecutive patients with PAES were treated surgically at Seoul National University Hospital between January 1994 and December 2009.

Successful percutaneous thrombectomy of an infected vena-caval thrombus due to a toothpick.

We report a case of a 25-year-old Caucasian female with a septic thrombosis in the inferior vena cava (IVC) which contained a toothpick. She was admitted with fever and abdominal pain for 2 weeks. Computed tomography scan showed thrombus with air density in the suprarenal IVC.

CYP3A5 *1 allele: impacts on early acute rejection and graft function in tacrolimus-based renal transplant recipients.

Background: Tacrolimus is a major immunosuppressant, which has a narrow therapeutic range and wide interindividual variation. The effects of genetic polymorphisms of cytochrome P450 3A (CYP3A) 5 and Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) genes on the achievement of target tacrolimus trough levels and clinical outcomes in renal transplants were evaluated.

Methods: A total of 62 patients participated in this prospective study.

Trends in deceased organ donation and utilization in Korea: 2000-2009.

Continuous efforts have been made by the organ donation and transplantation community in Korea to increase organ donation by the deceased. The authors detailed trends of organ donation and utilization over the past 10 yr using data provided by the KONOS. The yearly number of deceased donors has grown gradually since 2003.

Role of three-dimensional computed tomography venography as a powerful navigator for varicose vein surgery.

Purpose: Computed tomography venography (CTV) with three-dimensional reconstruction can provide complementary road maps for varicose vein (VV) surgery. The purpose of this study is to verify the role of CTV in the treatment of VV in terms of advantages and complications.

Methods: Ninety-four consecutive patients with VV underwent conventional high ligation, stripping, and varicosectomy by a single vascular surgeon in 2007.