Phase I/II study of a combination of capecitabine, cisplatin, and intraperitoneal docetaxel (XP ID) in advanced gastric cancer patients with peritoneal metastasis.

Background: This study was conducted to determine the recommended dose (RD) of intraperitoneal docetaxel (ID) in combination with systemic capecitabine and cisplatin (XP) and to evaluate its efficacy and safety at the RD in advanced gastric cancer (AGC) patients with peritoneal metastasis.

Methods: AGC patients with peritoneal metastasis received XP ID, which consists of 937.5 mg/m of capecitabine twice daily on days 1-14, 60 mg/m of intravenous cisplatin on day 1, and intraperitoneal docetaxel at 3 different dose levels (60, 80, or 100 mg/m) on day 1, every 3 weeks.

Differences in the prognosis of early gastric cancer according to sex and age.

Background: Few studies have compared early gastric cancer (EGC) outcomes according to sex and age.

Methods: We retrospectively reviewed 2085 patients who underwent curative gastrectomy for EGC between 1989 and 2000. Prognosis and risk factors for nodal involvement were evaluated according to sex and age.

Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients.

Background/aim: The aim of this study was to establish an appropriate TNM staging system for early gastric cancer.

Methodology: We evaluated 2124 patients who had undergone gastrectomy for early gastric cancer between 1989 and 2001.

Results: Using the seventh edition of the American Joint Committee on Cancer (AJCC) staging system, we found no significant differences in tumor recurrence and survival between N1 and N2 cancers or between N3a and N3b cancers, whereas the survival curves for N2 and N3 cancers were quite different.

Signet ring cell type and other histologic types: differing clinical course and prognosis in T1 gastric cancer.

Background: The behavior of early stage signet ring cell carcinoma (SRC) is controversial. The purpose of this study was to clarify the behavior of early gastric SRC.

Methods: We retrospectively analyzed data from 2,085 patients who had undergone curative gastrectomy for early gastric cancer between 1989 and 2000.

Appropriate gastrectomy resection margins for early gastric carcinoma.

Objective: In Korea and Japan, early gastric cancer (EGC) accounts for >50% of all gastric cancers. Here, we propose recommendations for the optimal distance from the tumor to the resection margins when evaluating EGC.

Summary Of Background Data: There are very few guidelines regarding the distance from the EGC tumor to the resection margins.

Gastric cancer staging at multi-detector row CT gastrography: comparison of transverse and volumetric CT scanning.

Purpose: To prospectively evaluate the accuracy of multi-detector row computed tomography (CT) gastrography for preoperative staging of gastric cancer, with pathologic and surgical results as the reference standard.

Materials And Methods: This study was approved by the institutional review board, and patients gave written informed consent. One hundred six patients (72 male, 34 female; mean age, 56 years) with endoscopically proved gastric cancer underwent unenhanced and contrast material-enhanced multi-detector row CT gastrography, with effervescent granules used as oral contrast material.

Effect of asymmetric stress relaxation on the polarization-dependent transmission characteristics of a CO2 laser-written long-period fiber grating.

The effect of stress-induced birefringence on polarization-dependent transmission characteristics was thoroughly investigated for a long-period fiber grating (LPFG) that was fabricated by use of a stress relaxation method with a CO2 laser. A series of two-dimensional axial stress profiles for one complete period of a LPFG was measured with an optical tomographic measurement technique. We found that the asymmetry in the stress distribution of the cladding was much larger than in the core of the LPFG.