Anti-inflammatory effect of remifentanil in lipopolysaccharide-stimulated amniotic epithelial cells.

Background: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that can cause inflammation.

Remifentanil reduced the effects of hydrogen peroxide-induced oxidative stress in human keratinocytes via autophagy.

Purpose: Excess reactive oxygen species are detrimental to wound repair. Remifentanil decreases reactive oxygen species generation and inflammatory response; however, its effects on oxidative cell injury are not completely understood. Therefore, we investigated the effects of remifentanil on human keratinocytes under hydrogen peroxide-induced oxidative stress and the correlation of these effects with autophagy.