Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica.

Phytochemical isolation of fermented (FAS) which was produced by using subsp. , exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation of Th₁/Th₂ cytokines and IgE in blood) of FAS and the barks of extract (AS) and the two diarylheptanoids, hirsutenone () and muricarpon B (), which are major components of FAS, were measured in vitro and in vivo.

Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of .

Chromatographic isolation of the 80% MeOH extract of (AG) yielded seven galloyl derivatives: gallic acid (), ginnalin B (), acertannin (), maplexin D (), maplexin E (), quercetin-3--(2''-galloyl)--L-rhamnopyranoside (), and kaempferol-3--(2''-galloyl)--L-rhamnopyranoside (). This is the first study to report the isolation of compounds and from AG. Galloyl derivatives - exhibited potent radical scavenging activities, with and showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.