An Adaptive Filter Based Motion Artifact Cancellation Technique Using Multi-Wavelength PPG for Accurate HR Estimation.

This article presents a motion artifact (MA) cancellation technique for accurate photoplethysmography (PPG)-based heart rate (HR) estimation. The MA is canceled using two PPG signals, measured with closely placed red and green LEDs. The proposed technique utilizes the characteristics of the two PPG signals: the high correlation in MA and their different AC/DC ratios.

Optimizing and determining the click chemistry mediated Cu-64 radiolabeling and physiochemical characteristics of trastuzumab conjugates.

Over the last decade, Cu-labeling of monoclonal antibody (mAb) via inverse electron demand Diels-Alder click chemistry (IEDDA) have received much attention. Despite the tetrazine-transcyclooctene (Tz-TCO) click chemistry's convenience and efficiency in mAb labeling, there is limited information about the ideal parameters in the development of click chemistry mediated (radio)immunoconjugates. This encourages us to conduct a systematic optimization while concurrently determining the physiochemical characteristics of the model mAb, trastuzumab, and TCO conjugates.

In vivo detection of hydrogen sulfide in the brain of live mouse: application in neuroinflammation models.

Purpose: Hydrogen sulfide (HS) plays important roles in brain pathophysiology. However, nuclear imaging probes for the in vivo detection of brain HS in living animals have not been developed. Here, we report the first nuclear imaging probe that enables in vivo imaging of endogenous HS in the brain of live mice.

Associations of Circulating Levels of Sphingosine 1-Phosphate with the Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women.

Despite the potential roles of sphingosine 1-phosphate (S1P) as a biomarker of osteoporotic fracture (OF), independent of bone mineral density (BMD) and clinical risk factors (CRFs), its association with bone microarchitecture, a key determinant of bone quality, have not been studied yet. We here investigated the association of S1P with the trabecular bone score (TBS), an index of the bone microarchitecture. The plasma S1P concentrations, TBS, and BMD were measured in the 339 postmenopausal women.

High Circulating Sphingosine 1-Phosphate is a Risk Factor for Osteoporotic Fracture Independent of Fracture Risk Assessment Tool.

Circulating sphingosine 1-phosphate (S1P) levels may be a biomarker for osteoporotic fracture (OF). This study assessed whether the addition of S1P levels to the fracture risk assessment tool (FRAX) could improve predictability of OF risk. Plasma S1P concentrations and FRAX variables were measured in 81 subjects with and 341 subjects without OF.

A Low-Power Photoplethysmogram-Based Heart Rate Sensor Using Heartbeat Locked Loop.

In this paper, we present an ultralow power heart rate (HR) monitoring photoplethysmography (PPG) sensor using a heartbeat locked loop (HBLL). The HBLL generates a narrow window that turns on the LED and analog-front-end only when a peak is expected in the PPG signal. The prototype PPG sensor implemented in 0.

The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia.

Background: Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient-controlled analgesia (PCA) following caesarean section.

Methods: Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section.

Effect of epidural magnesium on the incidence of chronic postoperative pain after video-assisted thoracic surgery.

Objective: The aim of this study was to determine whether the epidural administration of magnesium during the perioperative period decreased the incidence of chronic postoperative pain (CPOP) at 3 months after video-assisted thoracic surgery.

Design: Prospective, randomized, and blinded.

Setting: A university hospital.