Publications by authors named "Seona M Rossi"
Article Synopsis
- Cancer drug treatments often have harmful side effects and struggle to reach tumors effectively, but loco-regional drug delivery could enhance effectiveness and minimize toxicity.
- Techniques like intra-arterial delivery, direct injections for specific cancers, and HIPEC are being explored to improve treatment outcomes.
- Although the development of these delivery systems has faced challenges, recent advancements and a focus on personalized drug-delivery platforms show great promise, especially with the rise of immunotherapies.
Background: Minimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response to temperature, has been proposed as a potential treatment modality for solid tumours. The aim of this study was to assess the inherent cytotoxicity of a poloxamer-based thermoresponsive hydrogel in a murine xenograft model of lung cancer.
Methods: In vitro viability assessment was carried out in a lung cancer (A549) and non-cancerous (Balb/c 3T3 clone A31) cell line.
Purpose: Thermoresponsive hydrogels are gels which have different properties at varying temperatures. The objective of this study was to assess the material characteristics, imaging properties and chemotherapeutic drug release profile of a novel radiopaque thermoresponsive hydrogel in vitro, which is liquid at room temperature but solidifies at body temperature, to determine potential suitability for intratumoural delivery.
Materials And Methods: An iodinated radiopaque thermoresponsive hydrogel was formulated using iodixanol at a range of concentrations and assessed for sol-gel transition, radiopacity and imaging using CT and US.