Effects of Early Life Stress on Epigenetic Changes of the Glucocorticoid Receptor 1 Promoter during Adulthood.

Growing evidence suggests that early life stress (ELS) has long-lasting effects on glucocorticoid receptor (GR) expression and behavior via epigenetic changes of the GR exon 1 promoter. However, it remains unclear whether ELS regulates histone modifications of the GR exon 1 promoter across the life span. We investigated the effects of maternal separation (MS) on histone acetylation and methylation of GR exon 1 promoter in the hippocampus, according to the age of adults.

Parameters that affect macromolecular self-assembly of prion protein.

Amyloidogenesis of prion protein (PrP) is closely associated with the pathobiology of prion diseases. To understand details on formation of PrP amyloids, we investigated various conditions that influence the process in vitro, using full length and truncated recombinant PrP. Disrupted agitation and fluctuated temperature resulted in prolongation of lag phase during PrP amyloid formation.