Publications by authors named "Seon Y Park"

Background: Breakfast is vital for young children's health. In Australia, breakfast is often provided in government-approved Early Childhood Education and Care (ECEC) services. However, research on breakfast provision in Australian ECEC services is limited.

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Shiga toxin-producing (STEC) infections have increased in humans, animals, and the food industry, with ready-to-eat (RTE) food products being particularly susceptible to contamination. The prevalence of multidrug-resistant strains has rendered the current control strategies insufficient to effectively control STEC infections. Herein, we characterized the newly isolated STEC phage vB_ESM-pEJ01, a polyvalent phage capable of infecting and species, and assessed its efficacy in reducing STEC in vitro and food matrices.

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The growing threat of antimicrobial resistance (AMR), exacerbated by the COVID-19 pandemic, highlights the urgent need for alternative treatments such as bacteriophage (phage) therapy. Phage therapy offers a targeted approach to combat bacterial infections, particularly those resistant to conventional antibiotics. This study aimed to standardize an agar plate method for high-mix, low-volume phage production, suitable for personalized phage therapy.

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Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells.

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  • AHPND (Acute hepatopancreatic necrosis disease) is a major threat to the global shrimp industry, with new mutant strains causing concern over potential misdiagnosis and unexpected virulence.
  • This study reports the first identification of a natural mutant strain (20-082A3) in Korea, closely related to a previously virulent strain (19-021-D1) from a 2019 outbreak, sharing over 99.9% similarity in plasmids and the same genetic typing.
  • The newly identified mutant strain (20-082A3) does not cause symptoms or mortality in shrimp, indicating a need for ongoing surveillance of AHPND-causing pathogens in Korea and more research into the implications of this
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  • - Colonoscopy is crucial for early colorectal cancer detection, but the procedure's discomfort often necessitates sedation, prompting a study on different sedation protocols.
  • - In a trial with 51 patients, two groups received either midazolam with propofol or midazolam with pethidine, finding similar safety and effectiveness between both regimens.
  • - The midazolam and propofol group experienced fewer postural changes and needed less manual compression, suggesting it led to a more comfortable procedure without significant differences in pain or overall satisfaction.
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Vibrio parahaemolyticus is a major seafood-borne zoonotic pathogen that causes gastroenteritis in humans and acute hepatopancreatic necrosis disease (AHPND) in shrimp. In this study, we isolated and characterized Vibrio phage vB_VpM-pA2SJ1, which infects clinical and AHPND-associated strains of V. parahaemolyticus.

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Objective: This study investigated the neurocognitive characteristics of patients who visited an outpatient clinic requesting diagnosis and treatment for adult attention-deficit/hyperactivity disorder (ADHD).

Methods: The patients' electronic medical records were retrospectively reviewed. Neurocognitive test results were compared using Student's t-test according to their chief complaint, depressive symptoms, childhood history, and intelligence quotient (IQ).

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  • Hyperinflammation plays a key role in sepsis, impacting outcomes positively and negatively; researchers previously identified exosome-based super-repressor IκBα (Exo-srIκB) as a promising treatment.
  • In a rat model simulating polymicrobial sepsis, the study tested Exo-srIκB on different severities of sepsis and at various time points post-infection.
  • Results showed significant survival benefits with Exo-srIκB, particularly when given 6 hours post-infection in severe sepsis, along with reductions in harmful cytokines and improvements in critical blood markers.
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Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. Recent research has focused on targeting the pathways involved in oxidative stress, inflammation, and metastasis to enhance the survival of CRC patients.

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The increasing economic losses associated with growth retardation caused by (EHP), a microsporidian parasite infecting penaeid shrimp, require effective monitoring. The internal transcribed spacer (ITS)-1 region, the non-coding region of ribosomal clusters between 18S and 5.8S rRNA genes, is widely used in phylogenetic studies due to its high variability.

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  • - Donor lymphocyte infusion (DLI) is used to enhance the immune response against tumors and maintain donor stem cell presence but can lead to graft-versus-host disease (GVHD), affecting organs like the skin, intestine, and liver.
  • - An unusual case was reported where a patient with relapsed multiple myeloma developed acute severe liver dysfunction and semicoma after DLI, despite having previously managed their chronic hepatitis B with antiviral treatment.
  • - The patient improved after high-dose glucocorticoids were administered to treat the hepatic GVHD, highlighting the importance for clinicians to recognize this rare but serious complication after DLI in patients with blood disorders.
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Gastric cancer, a leading cause of cancer-related deaths globally, necessitates effective and early detection and treatment strategies. Endoscopic resection techniques, particularly endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), have evolved significantly, enhancing the treatment of gastric neoplasms. Underwater endoscopic mucosal resection (UEMR) is a widely used technique for the resection of duodenal and colorectal neoplasms.

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Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory pruritic skin disease. The available treatments for CAD have several adverse effects and vary in efficacy, indicating the need for the development of improved treatments. In this study, we aimed to elucidate the therapeutic effects of allogeneic and xenogeneic exosomes on CAD.

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To identify an economically viable waste management system for bioplastics, thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were anaerobically digested under hydrogen (H)/carbon dioxide (CO) and nitrogen (N) gas-purged conditions to compare methane (CH) production and biodegradation. Regardless of the type of bioplastics, CH production was consistently higher with H/CO than with N. The highest amount of CH was produced at 307.

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Background: This study aims to investigate the potential anti-inflammatory effects of exosomes engineered to carry super-repressor IκB (Exo-srIκB), an exosome-based NF-κB inhibitor, in the context of RA.

Methods: Peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) were collected from patients diagnosed with RA and treated with Exo-srIκB to test the therapeutic potential. Flow cytometry analysis was performed to assess the production of inflammatory cytokines (IL-17A and GM-CSF) by the cells.

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Amine derivatives are signature organic compounds generated from rotten protein food. Thus, sensitive detection of the presence of amines in protein foods can be a critical technique for monitoring their quality. In this study, we develop an organic chemosensor probe, 4-(2-(3-(dicyanomethylene)- 5,5-dimethylcyclohex-1-en-1-yl)vinyl)-N,N-diethylbenzenaminium chloride (DEAH), to effectively detect amines through discernible bimodal (colorimetric and fluorometric) changes.

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Introduction: The binary PirA/PirB toxin expressed by (PirAB) is a virulent complex that causes acute hepatopancreatic necrosis disease (AHPND) in shrimps, affecting the global shrimp farming industry. AHPND is currently diagnosed by detecting and genes by PCR; however, several strains do not produce the two toxins as proteins. Thus, an immunoassay using antibodies may be the most effective tool for detecting toxin molecules.

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Mammaliicoccus sciuri is an opportunistic zoonotic pathogen in humans and animals. We isolated the Mammaliicoccus phage vB_MscM-PMS3, which was also able to infect and lyse M. sciuri and M.

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Src is emerging as a promising target in triple-negative breast cancer (TNBC) treatment because it activates survival signaling linked to the epidermal growth factor receptor. In this study, the effect of calcium supply on Src degradation was investigated to confirm underlying mechanisms and anticancer effects targeting TNBC. MDA-MB-231 cells, the TNBC cell line, were used.

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Breakfast is considered a healthy dietary habit which can track over time from childhood to adulthood. The breakfast meal has the potential to improve daily dietary quality, particularly if it includes a range of food groups and adequate nutrient intakes. However, research on breakfast consumption trends among young Australian children aged up to 5 years is currently limited.

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Conflicting results regarding sex-based differences in the outcomes of out-of-hospital cardiac arrest (OHCA) patients have been reported. We aimed to evaluate the association between sex and neurological outcome as well as various in-hospital process in OHCA patients treated with targeted temperature management. We retrospectively analyzed a prospective registry data collected between October 2015 and December 2018.

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Streptococcus bovis/equinus complex (SBSEC) is one of the most important lactic acid-producing rumen bacteria causing subacute ruminal acidosis. Despite the significance of the ruminal bacteria, lytic bacteriophages (phages) capable of infecting SBSEC in the rumen have been rarely characterized. Hence, we describe the biological and genomic characteristics of two lytic phages (designated as vB_SbRt-pBovineB21 and vB_SbRt-pBovineS21) infecting various SBSEC species, including the newly reported S.

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After the concept of "Internet addiction" was first proposed in 2004, "Internet gaming disorder" (IGD) was included in the () as a disorder requiring further research. IGD is prevalent in South Korea, and many studies have been conducted on the disorder. Previous studies have helped in understanding various aspects of IGD, but a comprehensive understanding of the research trends is required to identify research gaps.

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Ni-rich cathodes are the most promising candidates for realizing high-energy-density Li-ion batteries. However, the high-valence Ni ions formed in highly delithiated states are prone to reduction to lower valence states, such as Ni and Ni , which may cause lattice oxygen loss, cation mixing, and Ni ion dissolution. Further, LiPF , a key salt in commercialized electrolytes, undergoes hydrolysis to produce acidic compounds, which accelerate Ni-ion dissolution and the interfacial deterioration of the Ni-rich cathode.

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