Publications by authors named "Seon Myeong Lee"
Macroautophagy/autophagy plays a vital role in the homeostasis of diverse cell types. Vascular endothelial cells contribute to vascular health and play a unique role in vascular biology. Here, we demonstrated that autophagy defects in endothelial cells induced IL6 (interleukin 6)-dependent endothelial-to-mesenchymal transition (EndMT) and organ fibrosis with metabolic defects in mice.
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- Recent research indicates that high levels of plasminogen activator inhibitor 1 (PAI-1) contribute to obesity-related non-alcoholic fatty liver disease (NAFLD) and metabolic disorders.
- In a study, mice fed a high-fat diet were treated with TM5441, a new oral PAI-1 inhibitor, which showed beneficial effects on liver health and insulin sensitivity.
- Both early and delayed treatments with TM5441 reduced liver fat accumulation and inflammation, improved mitochondrial function, and enhanced insulin sensitivity, suggesting it could be a promising therapy for managing HFD-induced NAFLD.
Aims/hypothesis: The efficacy of a low-protein diet (LPD) on diabetic nephropathy is controversial. We aimed to investigate the renoprotective effects of an LPD and the underlying molecular mechanism in a rat model of type 2 diabetes and obesity.
Methods: Diabetic male Wistar fatty (fa/fa) rats (WFRs) were treated with a standard diet (23.