Publications by authors named "Seom Gim Kong"
Several guidelines classify autologous stem cell transplantation (ASCT) as a low to intermediate risk group for infection. In a nationwide population-based study, using the Korean Health Insurance Review and Assessment Service database, patients with lymphoma and multiple myeloma (MM) who underwent ASCT from 2002 to 2016 were retrospectively analyzed. Cumulative incidence rates (CIRs) and risk factors of opportunistic infections were investigated.
View Article and Find Full Text PDFBackground/aims: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea and assess the efficacy of defibrotide.
Methods: Patients diagnosed with VOD/SOS after allogenic HCT between 2003 and 2020 were enrolled.
Background: Injury is the leading cause of death or disability in children and adolescents. Rates of deaths from injuries have recently declined, but studies of the occurrence of nonfatal injuries are lacking.
Purpose: This study aimed to investigate nonfatal injuries in children and adolescents younger than 20 years based on data from the Korean National Health and Nutrition Survey, 2007-2018.
Article Synopsis
- Acute promyelocytic leukemia (APL) is a rare form of leukemia in children, and a study evaluated its characteristics and outcomes in 79 pediatric patients in Korea between 2009 and 2016.
- The study found that 9.9% of children with acute myeloid leukemia had APL, with a median diagnosis age of 10.6 years, and most patients achieved complete remission (86.8%) after treatment, though some experienced serious complications.
- Key findings indicate that initial white blood cell (WBC) count was a significant prognostic factor, influencing survival, with a 4-year overall survival rate of 89.7%.
Background: Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60-80% of TRM occurs early, within 100 days of transplantation.
Methods: This was a nationwide population cohort study involving 5395 patients with acute leukemia who underwent allo-HCT between 2003 and 2015.
Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed a retrospective cohort study using a national population-based database.
View Article and Find Full Text PDFChanges in the prevalence of anemia in Korean adolescents, 1998-2018.
Clin Exp Pediatr
February 2021
Background: Anemia is an important health problem affecting approximately 25% of the global population. Although its prevalence is decreasing worldwide, few studies have examined the prevalence of anemia in Korean adolescents.
Purpose: This study aimed to determine the prevalence of anemia in Korean adolescents over the past 21 years using data from the Korea National Health and Nutrition Examination Survey.
Article Synopsis
- Hereditary hemolytic anemia (HHA) is a rare condition marked by early breakdown of red blood cells, and a study aimed to examine its prevalence in Korea from 2007 to 2016.
- Data was collected from 369 children with HHA across multiple hospitals, revealing that the majority had RBC membranopathies, with significant increases in hemoglobinopathies and RBC enzymopathies compared to a previous decade.
- The study noted an uptick in thalassemia traits, linked to greater awareness and international marriages, while emphasizing the need to improve diagnostic access for the 6.5% of patients without a clear diagnosis.
Mortality at an early stage after kidney transplantation is a catastrophic event. Treatment-related mortality (TRM) within 1 or 3 months after kidney transplantation has been seldom reported. We designed a retrospective observational cohort study using a national population-based database, which included information about all kidney recipients between 2003 and 2016.
View Article and Find Full Text PDFBackground: The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes of death of patients with WM.
Methods: We used a national population-based database, operated by the Health Insurance Review and Assessment Service of the Korean government.
Acute lymphoblastic leukemia (ALL) with hyperleukocytosis at diagnosis is associated with early morbidity and mortality due to complications of leukostasis. Of 535 pediatric ALL patients (January 2004 to December 2016 from the Yeungnam region of Korea), 72 (13.5%) patients with an initial white blood cell (WBC) count of ≥100×10/L were included in this study, of whom 38 patients had extreme hyperleukocytosis (WBC>200×10/L) at diagnosis.
View Article and Find Full Text PDFObjectives: We aimed to evaluate treatment outcomes of pediatric acute lymphoblastic leukemia (ALL) subgroups by risk-stratification, in the Yeungnam region of Korea.
Methods: We reviewed the courses of 409 newly diagnosed ALL patients from January 2004 to December 2013 in the Yeungnam region.
Results: All patients were classified into three risk groups: standard risk (SR, n=212), high risk (HR, n=153) and very high risk (VHR, n=44).
Article Synopsis
- Thalassemia, a blood disorder more common in Southeast Asia, is gaining attention in Korea due to a rise in Southeast Asian immigrants, prompting this study to examine its prevalence.
- The study analyzed 669 individuals under 30, comparing findings between multiethnic and Korean groups, and performed tests for thalassemia-related gene mutations on those with abnormal blood results.
- Results showed a small percentage of thalassemia carriers among multiethnic subjects (1.5% for α-thalassemia and 1.9% for β-thalassemia minor), indicating an increase in thalassemia cases linked to immigration trends.
Background: Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor () rearrangement in Korean T-ALL patients by fragment analysis, examining frequency, association between clinicopathologic characteristics and clonality, and feasibility for detecting minimal residual disease (MRD).
Methods: In 51 Korean patients diagnosed as having T-ALL, rearrangement was analyzed using the IdentiClone gene clonality assay (InVivoScribe Technologies, San Diego, CA, USA) from archived bone marrow specimens.
Purpose: The use of proper safety restraint systems by children is vital for the reduction of traffic accident-related injury and death. This study evaluated the rates of use of safety restraint systems and front seats by Korean children.
Methods: Based on data from the National Health and Nutrition Examination Survey from 2008 to 2015, I investigated the frequencies of safety restraint systems and front seat use by children under six and 12 years of age, respectively.
Background: Hyperleukocytosis caused by acute lymphoblastic leukemia (ALL) is associated with early morbidity and mortality due to hyperviscosity arising from the excessive number of leukocytes.This study was designed to assess the incidence of hyperleukocytosis, survival outcomes, and adverse features among pediatric ALL patients with hyperleukocytosis.
Methods: Between January 2001 and December 2010, 104 children with previously untreated ALL were enrolled at the Pusan National University Hospital.
Background: This study investigated the clinical characteristics and risk factors of the severity of pandemic influenza A (H1N1) 2009 infection in pediatric patients in Busan and Gyeongsangnam-do.
Methods: Cases of influenza A (H1N1) 2009 in patients under the age of 18 years, confirmed by reverse transcription polymerase chain reaction, at Pusan National University Hospital and Pusan National University Yangsan Hospital from the last week of August 2009 through the last week of February 2010 were retrospectively analyzed.
Results: Of the 3,777 confirmed cases of influenza A (H1N1) 2009, 2,200 (58.