Publications by authors named "Seokwhi Kim"
J Exp Clin Cancer Res
December 2019
Article Synopsis
- Research shows that the loss of PTPRD, a protein commonly inactivated in gastric cancers (GCs), is linked to more severe cancer stages and increased metastasis risk.
- The study identified that the absence of PTPRD leads to higher CXCL8 expression, promoting angiogenesis (formation of new blood vessels) through specific signaling pathways (ERK and STAT3).
- Metformin has been highlighted as a potential treatment, effectively inhibiting angiogenesis and improving cell viability in cancers lacking PTPRD, suggesting further exploration of its therapeutic benefits.
