Publications by authors named "Seok-Man Son"
Background/aim: The association between preoperative ultrasound (US) echogenicity and histopathological characteristics of papillary thyroid cancer (PTC) has been rarely investigated is not well characterized. This study evaluated a relationship between the clinical characteristics of PTC, histopathological phenomena including tumor growth patterns (TGPs) and tumor fibrosis (TF), and US echogenicity.
Patients And Methods: In total, 170 patients with PTC (<2 cm) underwent total thyroidectomy with central neck dissection.
Article Synopsis
- The study investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) in Korean adults, finding that 10% of participants had NAFLD, diagnosed with a fatty liver index (FLI) of 60 or higher.
- Results showed a strong association between higher FLI values and increased risk for hypertension, diabetes, and metabolic syndrome (MetS), with higher FLI groups experiencing significantly worse health outcomes.
- The study concluded that FLI could serve as an effective screening tool for identifying individuals at risk for metabolic disorders, suggesting a cutoff value of 20 for predicting MetS presence.
Purpose: Muscles play an important role in energy metabolism. Several studies have investigated the association between muscle mass and metabolic syndrome (MetS), reporting conflicting results. However, studies concerning the association between muscle strength and MetS are limited.
View Article and Find Full Text PDFAssociation between serum cystatin C and bone mineral density in Korean adults.
Ther Clin Risk Manag
November 2017
Background: Serum cystatin C has been known as a novel marker of preclinical renal dysfunction, and higher cystatin C levels are associated with increased risks of hip and nonvertebral fractures. However, there are few reports on the association between serum cystatin C and bone mineral density (BMD), especially in the Asian population. We evaluated the association between cystatin C levels and BMD of the spine and hip in Korean adults.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on nonalbuminuric renal insufficiency in Korean patients with type 2 diabetes and its link to cardiovascular disease (CVD) events.
- Participants were analyzed based on their chronic kidney disease (CKD) stages, revealing differences in factors like diabetic duration and prior health conditions.
- Findings suggest that nonalbuminuric CKD stage ≥3 shows a strong correlation with previous CVD events, and both decreased eGFR and increased albuminuria significantly raise the risk of such events.
Article Synopsis
- Metabolic syndrome (MetS) is linked to an increased prevalence of reduced kidney function in Korean adults, as assessed by different eGFR methods (creatinine, cystatin C, and combined).
- Older age correlates with higher occurrences of reduced kidney function, particularly in individuals with MetS and its specific components like abdominal obesity and hypertension.
- The study found that cystatin C-based eGFR methods are more effective than creatinine-based methods for identifying reduced kidney function in people with MetS.
Conclusion Loco-regional recurrence-free survival was significantly decreased in the papillary thyroid cancer patients with > 6 metastatic lymph nodes and a lymph node ratio > 0.22. Also, the risk of lung metastasis was significantly increased in cases with bilateral neck node metastases.
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- Cystatin C is linked to early renal impairment and is potentially associated with higher prevalence of diabetes and prediabetes among Korean adults.
- Data from 1,559 participants showed that those with elevated cystatin C levels had significantly higher rates of diabetes (10.6%) and prediabetes (30.2%) compared to those with normal levels.
- The study suggests that higher serum cystatin C levels may indicate an increased risk for diabetic conditions in Asian populations, particularly in women, although results varied after adjusting for other factors.
Background: The purpose of this study was to present our focus on the lymph node status in the central compartment and evaluate the relevant factors and disease recurrence.
Methods: Between January 2004 and December 2009, 1040 patients were diagnosed with papillary thyroid carcinoma (PTC) and underwent surgery.
Results: The number of metastatic lymph nodes was a significant predictor for recurrence conferring a hazard ratio of 1.
Background: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor receptor superfamily and its serum level is known to be closely associated with future cardiovascular events and prognosis of various cardiovascular diseases. We investigated whether serum TRAIL levels are associated with the severity of acute ischemic stroke and specific stroke subtype.
Methods: We used an enzyme-linked immunosorbent assay to measure the serum TRAIL levels of 293 patients with acute ischemic stroke within 7 days of onset.
Article Synopsis
- The study investigates the impact of high glucose (HG) and phosphate (HP) levels on vascular calcification in rat vascular smooth muscle cells over 2 to 4 weeks.
- It finds increased calcium deposition in VSMCs when exposed to HG and HP, with a notable decrease in OPG expression after 4 weeks, suggesting its role in vascular mineralization.
- Long-term stimulation leads to a reduction in OPG levels, potentially enhancing osteo-inductive differentiation in VSMCs, indicated by increased alkaline phosphatase (ALP) activity associated with vascular calcification.
Background: Increased serum ferritin and decreased vitamin D levels associated with nonalcoholic fatty liver disease (NAFLD). However, their association with the severity of NAFLD has not been fully evaluated. The aim of this study was to compare the association of serum ferritin and 25(OH)D₃ levels with the severity of ultrasonographically detected NAFLD (US-NAFLD) and hepatic steatosis defined by fatty liver index (FLI) in Korean adults.
View Article and Find Full Text PDFBackground: In thyroid cancer, preoperative ultrasonography (US) is performed to detect the primary tumor and lymph node metastasis (LNM), which are related to prognosis. This study examined the relationships between specific US findings and LNM in micropapillary thyroid cancer (MPTC).
Methods: Data on 220 patients with solitary MPTC who underwent total thyroidectomy and neck dissection between 2008 and 2009 were evaluated retrospectively.
Background: Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC.
Methods: We reviewed 131 patients who underwent total thyroidectomy with CLN dissection and selective lymph node dissection.
Background: The status of metastatic lymph nodes, including the size and extracapsular spread (ECS), in papillary thyroid cancer (PTC) has not been well established. This study evaluated the correlation between the specific status of central lymph node metastases (CLNM) and negative prognostic factors.
Methods: We reviewed 243 patients who underwent total thyroidectomy and neck dissection.
Article Synopsis
- The study investigates the effectiveness of frozen biopsy in diagnosing central neck metastasis in patients with papillary thyroid cancer (PTC).
- Approximately 53% of the 252 patients studied showed central neck metastasis, with frozen biopsy demonstrating a high sensitivity (92%) and specificity (99%) for detecting it.
- The results indicate that frozen biopsy is a reliable method for accurately determining the number of metastatic lymph nodes during surgery, with a diagnostic accuracy of 91% compared to traditional permanent biopsy.
Reactive oxygen and nitrogen species in pathogenesis of vascular complications of diabetes.
Diabetes Metab J
June 2012
Article Synopsis
- Macrovascular and microvascular diseases are major causes of health issues and death in people with diabetes, linked to dysfunctions in reactive oxygen and nitrogen species.
- An imbalance in oxidative stress and antioxidant defenses can lead to cellular damage and complications in the vascular system of diabetic patients.
- There is potential for antioxidant therapy to help manage oxidative stress in diabetes, but more research is needed to find effective treatments to prevent or slow down vascular complications.
Article Synopsis
- ApoA-II, which is the second-most common apolipoprotein in HDL, has an unclear role in metabolic syndrome (MetS) and may have conflicting effects on cardiovascular health.
- The study analyzed data from 244 Korean adults and found that while apoB levels were higher and apoA-I levels were lower in those with MetS, apoA-II levels showed no significant differences or associations with MetS.
- Despite the lack of correlation, the study suggests that apoA-II could have both harmful and protective roles in cardiovascular health, differing from the clear associations seen with apoA-I and apoB.
Article Synopsis
- Distant lung metastasis in papillary thyroid cancer (PTC) is rare but critical for survival prognosis, prompting a study to identify risk factors.
- A retrospective analysis of 949 PTC patients found lung metastasis in 2.1%, with factors like male gender and large tumor size linked in univariate analysis, but bilaterally laterally cervical lymph node metastasis (BLNM) as the sole significant factor in multivariate analysis.
- Conclusions suggest that vigilant monitoring, including imaging, is essential for patients with suspected BLNM during follow-up.
Article Synopsis
- The study examined the occurrence of hidden lateral neck metastasis in patients with papillary thyroid carcinoma (PTC) that also had central neck metastasis, finding a 55% rate of occult lateral neck metastasis.
- Patients with lateral neck metastasis tended to have larger tumors and more positive central lymph nodes, while age and extrathyroidal extension did not show significant differences between groups.
- The findings suggest that tumor size and the number of positive bilateral central lymph nodes are key indicators for the likelihood of lateral neck metastasis, indicating that prophylactic lateral neck dissection may benefit certain patients.
Article Synopsis
- The study investigates the relationship between preoperative serum TSH levels and advanced features of well-differentiated thyroid cancer in a Korean population.
- Higher preoperative TSH levels were significantly linked to extrathyroidal extension and lateral lymph node metastasis in patients, indicating worsening disease characteristics.
- The findings suggest that measuring TSH levels could help predict the extent of surgery needed for thyroid cancer patients, highlighting TSH as a potential preoperative marker for better surgical planning.
Article Synopsis
- A 61-year-old woman with an incidental adrenal mass was found to have elevated serum cortisol and disturbed circadian rhythm, leading to further testing for adrenal function.
- After a dexamethasone suppression test caused severe hypertension and elevated catecholamines, she was diagnosed with pheochromocytoma, a type of adrenal tumor.
- Following a successful laparoscopic adrenalectomy, her catecholamine levels normalized, and she has remained healthy without medication, highlighting the importance of investigating potential functional masses in adrenal incidentalomas.