Publications by authors named "Seo Yeon Gwak"
Background: High-intensity physical activity has traditionally been discouraged in patients with hypertrophic cardiomyopathy due to concerns about triggering sudden cardiac death. However, current guidelines adopt a more liberal stance, and evidence on risk factors for exercise-related sudden cardiac death remains limited. This study investigated the clinical, morphological and genetic factors associated with high-intensity physical activity-related sudden cardiac death in hypertrophic cardiomyopathy.
View Article and Find Full Text PDFBackground: Hypertrophic cardiomyopathy (HCM) needs careful differentiation from other cardiomyopathies. Current guidelines recommend genetic testing, but genetic data on differential diagnoses and their relation with clinical outcomes in HCM are still lacking. This study aimed to investigate the prevalence of genetic variants and the proportion of other cardiomyopathies in patients with suspected HCM in Korea and compare the outcomes of HCM according to the presence of sarcomere gene mutation.
View Article and Find Full Text PDFSelecting the optimal candidates for percutaneous mitral valvuloplasty using multi-modality imaging.
Eur Heart J Cardiovasc Imaging
December 2024
Aims: This study compared echocardiography (echo) and cardiac computed tomography (CT) in measuring the Wilkins score and evaluated the potential added benefit of CT in predicting immediate percutaneous mitral valvuloplasty (PMV) outcomes in rheumatic mitral stenosis (MS) patients deemed eligible for PMV by echo.
Methods And Results: From a multicentre registry of 3,140 patients with at least moderate MS, we included 96 patients (age 56.4±11.
Background: In patients with tricuspid regurgitation (TR), delayed surgical intervention is associated with poor outcomes, particularly in advanced stages. This study aimed to assess whether earlier tricuspid valve (TV) surgery provides a survival benefit in patients with moderate to severe TR who are considered at low to intermediate risk of adverse clinical or surgical outcomes.
Methods: This retrospective cohort study included 10 016 patients diagnosed with moderate to severe TR between 2008 and 2020.
Incremental prognostic value of left ventricular and left atrial strains in moderate aortic stenosis.
Eur Heart J Cardiovasc Imaging
December 2024
Aims: Patients with moderate aortic stenosis (AS) show a poor prognosis if they have high-risk features. We investigated herein the incremental prognostic value of left ventricular (LV) and left atrial (LA) strain in patients with moderate AS.
Methods And Results: In a cohort of 923 patients with moderate AS (median age 74 years, men 55%, aortic valve area 1.
Article Synopsis
- South Korea's economic growth over the past two decades has affected the clinical profile of patients with rheumatic mitral stenosis (MS), leading to older patients with more severe conditions and comorbidities like hypertension and atrial fibrillation.
- Analysis of data from 2,337 patients showed that while the rate of mitral interventions increased, the overall clinical outcomes worsened, indicating a need for improved treatment strategies.
- Despite stable stroke incidence due to better anticoagulation therapy, the findings emphasize the challenges faced as the healthcare landscape transitions with the country’s development.
Article Synopsis
- Percutaneous mitral valvuloplasty (PMV) is an effective treatment for patients with severe rheumatic mitral stenosis (RMS), but the impact of changes in mitral valve area (∆MVA) during the procedure is not well understood.
- A study analyzed 308 patients from the MASTER registry, focusing on those undergoing their first PMV, and found that a ∆MVA greater than 0.5 cm² correlated with better long-term health outcomes.
- The research indicates that not only achieving optimal post-procedure results but also aiming for a significant increase in ∆MVA could improve patient prognosis in PMV surgeries.
Article Synopsis
- Malignant pericardial effusion (MPE) in cancer patients has a poor prognosis, and this study compares the effectiveness of two drainage methods: pericardiocentesis and pericardial window formation.
- The study analyzed 765 cancer patients who underwent pericardial drainage from 2003 to 2022, finding no significant difference in overall mortality between the two methods, but noted a lower recurrence rate of MPE with pericardial window formation (6.3% vs. 18.0%).
- Ultimately, the findings suggest that while both methods have similar mortality outcomes, pericardial window formation is more effective in reducing MPE recurrence, especially in recent years.
Article Synopsis
- This study compared the effectiveness of percutaneous mitral valvuloplasty (PMV) and mitral valve replacement (MVR) in treating severe mitral stenosis (MS) defined as mitral valve area (MVA) ≤ 1.5 cm, using data from the MASTER registry involving 3140 patients.
- The analysis focused on 442 patients, revealing that while primary outcomes like cardiovascular death and heart failure hospitalization were similar for both treatment options, MVR resulted in fewer secondary outcomes, particularly in very severe MS (VS-MS) cases.
- The study concluded that although neither treatment significantly impacted mortality or hospitalization rates, MVR may be preferred over PMV for VS-MS patients due to a higher need for redo interventions
Risk Factors and Outcomes With Progressive Mitral Annular Calcification.
J Am Heart Assoc
September 2023
Article Synopsis
- - The study investigated the progression of mitral annular calcification (MAC) in 138 patients, finding that 31.2% experienced significant worsening of their condition within 18-36 months.
- - Factors like higher systolic blood pressure, elevated MAC angle, and changes in left ventricular function were linked to MAC progression, indicating that hemodynamic stress contributes to the condition.
- - Patients with progressive MAC faced worse clinical outcomes, including higher rates of mortality and hospitalizations, compared to those with stable MAC.
Article Synopsis
- The study investigates the effect of septal reduction therapy on the mechanical function of the left atrium (LA) and left ventricle (LV) in patients with obstructive hypertrophic cardiomyopathy (HCM).
- Among 44 patients analyzed post-surgery, there was a significant decrease in LA volume and improvement in LA strain, indicating better mechanical function.
- However, LV function worsened, with a decrease in ejection fraction and global longitudinal strain, highlighting that while LA function improved, LV function deteriorated following the surgery.
Right ventricular myocarditis and rapid fibrosis induced by pazopanib.
Eur Heart J Cardiovasc Imaging
July 2023
Background: There are insufficient data regarding the risk factors associated with valve dysfunction of bioprosthetic valves in the mitral position This study aimed to investigate the factors associated with bioprosthetic mitral valve (MV) dysfunction (MVD).
Methods: A total of 245 patients (age 67.2±11.
Importance: Atrial fibrillation (AF) can develop following thoracic irradiation. However, the critical cardiac substructure responsible for AF has not been properly studied.
Objective: To describe the incidence of AF in patients with lung cancer and determine predictive cardiac dosimetric parameters.
Inflammatory pseudotumour originating from congenital double atrial septum.
Eur Heart J Cardiovasc Imaging
November 2022
Right ventricular compression by distended stomach: a rare cause of postprandial dyspnoea.
Eur Heart J Cardiovasc Imaging
October 2022
Objective: Patent foramen ovale (PFO) is often found in stroke patients with determined etiologies. PFO may be the actual cause of stroke in some of them. We determined whether the risk of recurrent ischemic stroke differs with PFO status in stroke patients with determined etiologies.
View Article and Find Full Text PDFThis is a case report of successful endoscopic resection (ER) of a bleeding duodenal lipoma. An 85-year-old woman who was diagnosed with asymptomatic subepithelial tumor of the duodenum 3 years ago visited the emergency room with hematemesis and was admitted to our hospital. Emergent esophagogastroduodenoscopy revealed bleeding from an ulcer on the superior aspect of a subepithelial tumor measuring about 20 mm in diameter, at the superior duodenal angle.
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