Publications by authors named "Seo Kyoung Park"

Article Synopsis
  • Ubiquitination modifies proteins with ubiquitin to regulate their degradation or functions, while deubiquitinating enzymes (DUBs) remove ubiquitin, influencing these processes.
  • USP2a, a DUB, is highlighted as a promising cancer therapy target, but effective inhibitors have been scarce.
  • The study focused on optimizing a USP2a inhibitor, ML364, resulting in compound 8v, which showed lower toxicity, reduced USP2a targets, decreased cancer cell growth, and selective inhibition of USP2a compared to other related proteins.
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Ocean acidification and warming represent major environmental threats to kelp mariculture. In this study, sporophytic photochemical efficiency and gametophytic growth of Saccharina japonica and Undaria pinnatifida were evaluated under different pCO levels (360, 720, and 980 ppmv) and temperatures (5, 10, 15, and 20 °C for sporophytes; 15 and 20 °C for gametophytes). Sporophytic photochemical efficiencies of both kelps were significantly greater at 720 ppmv than at 360 and 980 ppmv.

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We report a method to tailor chemically converted graphenes (CCGs) using a water-soluble pyrene derivative (1) with a zwitterionic arm, and the feasibility of the tailored CCGs to sensitive electrochemiluminescence (ECL)-based analyses. The compound 1 serves the dual purpose of improving the dispersion of the CCGs in aqueous solutions and further tailoring the catalytic activity of the CCGs with dendrimer-encapsulated catalytic nanoparticles. As a model system, we conjugated dendrimer-encapsulated Pt nanoparticles to the 1-functionalized CCGs on indium tin oxide (ITO) electrodes.

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